Results 51 to 60 of about 16,280 (231)

A patient with a bronchial carcinoid presents with Cushingoid symptoms due to an atypical and potentially dangerous supplement

Journal of Clinical and Translational Endocrinology Case Reports, 2023
Background: Well differentiated bronchial neuroendocrine neoplasms often follow a clinically indolent course and rarely cause ectopic ACTH syndrome. Iatrogenic corticosteroid use is the most common cause of Cushing syndrome and should be considered in ...
Tomas Morales, Shanika Samarasinghe
doaj   +1 more source

Factors predicting the duration of adrenal insufficiency in patients successfully treated for Cushing disease and nonmalignant primary adrenal Cushing syndrome [PDF]

, 2017
Successful treatment of Cushing syndrome causes transient or permanent adrenal insufficiency deriving from endogenous hypercortisolism-induced hypothalamus–pituitary–adrenal–axis suppression.
Pontecorvi, Alfredo, Rota, Carlo Antonio, Paragliola, Rosa Maria, Corsello, Salvatore Maria   +3 more
core   +1 more source

Fatty Liver Disease Along Cushing Syndrome Evolution [PDF]

International audienceAbstract Context The clinical manifestations of Cushing syndrome are variable, but an important number of patients present a metabolic syndrome, strongly associated with hepatic steatosis.
Marengo, Maria, Munier, Mathilde, Suteau, Valentine, Boursier, Jérôme, Briet, Claire, Rodien, Patrice   +5 more
core   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Cushing syndrome in children: Pathophysiology, clinical features, diagnostic and therapeutic strategies

Bioscientific Review, 2023
A rare condition called Cushing disease causes increased morbidity or mortality. Therapeutic methods such as anti-cortisol medications, bilateral adrenalectomy, or radiation procedures may therefore be required to prevent long-term dangers of ...
Sana Ashraf, Dr Shakeela Parveen, Saba Ashraf, Uzma Batool, Mehwish Sultana, Urwah Ishaque, Zainab Shafqat, Saman Shabbir, Zainab Riaz, Zunaira Faiz   +9 more
doaj  

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Coagulopathy in Cushing’s Syndrome [PDF]

Neuroendocrinology, 2010
A hypercoagulable state and its consequent increased incidence of thromboembolic complications are reported in patients with Cushing’s syndrome (CS). These alterations are related to cortisol excess that induces prothrombotic changes in blood by several and complex mechanisms including increased levels of clotting factors, mainly factor VIII and von ...
TREMENTINO L, ARNALDI G, APPOLLONI G, DAIDONE, VIVIANA, SCARONI, CARLA, CASONATO, SANDRA, BOSCARO, MARCO   +6 more
openaire   +3 more sources

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

A case of subclinical Cushing syndrome and multiple myeloma [PDF]

, 2007
Subclinical Cushing syndrome coexisting with multiple myeloma has not been not previously reported. This case report demonstrates the coexistence of these 2 diseases and the associated treatment dilemma.
Kebapcilar, Levent, Guengoer, Oezkan, Yesil, Sena, Demir, TEVFİK, Bayraktar, FIRAT, Coemlekci, Abdurrahman, Alacacioglu, İNCİ   +6 more
core   +1 more source