Results 61 to 70 of about 78,398 (277)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Sign changes of Fourier coefficients of Siegel cusp forms of degree two on Hecke congruence subgroups

open access: yes, 2017
In this article, the authors give a lower bound on the number of sign changes of Fourier coefficients of a non-zero degree two Siegel cusp form of even integral weight on a Hecke congruence subgroup.
Gun, S., Sengupta, J.
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Universality of zeta-functions of cusp forms and non-trivial zeros of the Riemann zeta-function

open access: yesMathematical Modelling and Analysis, 2021
It is known that zeta-functions ζ(s,F) of normalized Hecke-eigen cusp forms F are universal in the Voronin sense, i.e., their shifts ζ(s + iτ,F), τ ∈ R, approximate a wide class of analytic functions.
Aidas Balčiūnas   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Pulsed flows at the high-altitude cusp poleward boundary, and associated ionospheric convection and particle signatures, during a Cluster - FAST - SuperDARN- Søndrestrøm conjunction under a southwest IMF [PDF]

open access: yesAnnales Geophysicae, 2004
Particle and magnetic field observations during a magnetic conjunction Cluster 1-FAST-Søndrestrøm within the field of view of SuperDARN radars on 21 January 2001 allow us to draw a detailed, comprehensive and self-consistent picture at ...
C. J. Farrugia   +15 more
doaj   +1 more source

Quantitative quantum ergodicity and the nodal domains of Maass-Hecke cusp forms [PDF]

open access: yes, 2016
We prove a quantitative statement of the quantum ergodicity for Hecke--Maass cusp forms on the modular surface. As an application of our result, along a density $1$ subsequence of even Hecke--Maass cusp forms, we obtain a sharp lower bound for the $L^2 ...
Jung, Junehyuk
core  

Products of Eisenstein series and Fourier expansions of modular forms at cusps

open access: yes, 2018
We show, for levels of the form $N = p^a q^b N'$ with $N'$ squarefree, that in weights $k \geq 4$ every cusp form $f \in \mathcal{S}_k(N)$ is a linear combination of products of certain Eisenstein series of lower weight.
Dickson, Martin, Neururer, Michael
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

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