Results 61 to 70 of about 725,638 (247)

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

open access: yesAdvanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu   +5 more
wiley   +1 more source

Customer advocacy and brand development

open access: yes, 2006
Purpose – The purpose of this article is to define and explore the strategic value of customer advocacy through the lens of the brand management literature.  Design/methodology/approach – The paper reviews recent analysis of the value and vulnerabilities
Lawer, Christopher, Knox, Simon
core   +1 more source

Commercial Aircraft Maintenance System Construction and Its Application in Defense Equipment Logistic Support Domain from Civil-military Integration Point of View

open access: yesHangkong gongcheng jinzhan, 2018
With the rapid development of science and technology, the complexity of national defense equipment is increasing. It is difficult to complete the security task reasonably and effectively by the military security capability.
Wang Ying, Ma Xiaojun
doaj   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

open access: yesAdvanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen   +12 more
wiley   +1 more source

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

open access: yesAdvanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri   +3 more
wiley   +1 more source

Structural Divergence Between the Moltbook AI‐Agent Network and Human Social Networks

open access: yesAdvanced Science, EarlyView.
Analysis of the Moltbook AI‐agent network reveals a striking combination of familiar global scaling and distinct internal organization. Attention is highly concentrated, reciprocity is limited, connected triads are suppressed, and communities are strongly modular.
Wenpin Hou, Zhicheng Ji
wiley   +1 more source

Measuring and managing customer relationship risk in business markets. [PDF]

open access: yes, 2007
There have been repeated calls from top management and marketing academics for greater accountability in marketing so that the financial returns of marketing investments can be more robustly evaluated.
Ryals, Lynette, Knox, Simon
core   +1 more source

Establishment method of civil aircraft abnormal operation procedure items

open access: yesHangkong gongcheng jinzhan
Abnormal procedures are the important basis for the flight crew to handle emergency conditions. There is no current establishment method of procedures items,which makes redundancy or omission may easily occur in the procedure items.
ZHANG Congyuan, YANG Yanyan
doaj   +1 more source

FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence‐Associated Factor pMGF300‐2R

open access: yesAdvanced Science, EarlyView.
ABSTRACT African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA ...
Rui Luo   +9 more
wiley   +1 more source

Improving Customer Satisfaction: Changes as a Result of Customer Value Discovery [PDF]

open access: yes, 2008
Objective: To identify Gold Standard Services for customers in an academic library and determine whether interventions following the identification of customer value increased student satisfaction.Methods: “Customer Discovery Workshops” were undertaken ...
McKnight, S   +3 more
core  

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