Results 71 to 80 of about 89,221 (288)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

The Organization in Economy of Knowledge

open access: yesВестник Российского экономического университета имени Г. В. Плеханова, 2019
The article deals with changes, which will happen to the organization at the new stage of the economic development, i. e. in economy of knowledge.
O. E. Kalenov
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

CONSUMER BEHAVIOUR FORMATION IN THE CUSTOMIZED SERVICE MARKETS: A CASE OF UKRAINE [PDF]

open access: yesBaltic Journal of Economic Studies, 2018
Target setting. In modern conditions, in some markets for goods in mass demand, companies are increasingly beginning to introduce customization in marketing activities, which involves the implementation of marketing tools aimed at ensuring a wide ...
Victoria Zhurylo, Olga Prygara
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

The Impact of social media platforms on consumer purchasing behavior in online shopping [PDF]

open access: yesERU Research Journal
This research aims to investigate the impact of social media channels on consumer behavior. This research is quantitative and qualitative; the data is collected by conducting a survey and interview. Primary data is collected by questionnaires distributed
Alaa Hassan
doaj   +1 more source

Customization Management Study of Aircraft Based on Product Structure Theory

open access: yesHangkong gongcheng jinzhan, 2020
Airline has different demands for market choose, brand construction, flight course and equipment selection, which leads a lot of diversity configuration for different aircraft or different block of aircraft, so the flexibility and high efficiency ...
XU Songlin, ZHOU Jian
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Customizing Your Demons: Anxiety Reduction via Anthropomorphizing and Destroying an “Anxiety Avatar”

open access: yesFrontiers in Psychology, 2020
Character customization is a prominent feature in digital games, affording users the ability to tailor one’s virtual self-representation (avatar) to match aspects of their actual or ideal self, influencing psychological well-being.
Daniel Pimentel, Sri Kalyanaraman
doaj   +1 more source

Exploring Mass Message Customization [PDF]

open access: yes
The paper begins with the exploratory concept of ‘mass customization’ and then moves on to discuss the possibility of applying it in business communication. Further, it gives a brief framework within which to fit this concept.
Nande Kaustubh
core  

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