Results 61 to 70 of about 89,221 (288)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
ESTIMATION OF ECONOMIC EFFECTS FROM PRODUCT CUSTOMIZATION OF RUSSIAN INDUSTRIAL ENTERPRISES
Стратегические решения и риск-менеджмент, 2022 The development of digital production technologies, taking place within the framework of the global fourth industrial revolution, creates conditions for increasing the level of customization of industrial production, i.e.
S. A. Titov, N. V. Titova
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Optimal Software Versioning Strategy Considering Customization and Consumer Deliberation Behavior
Journal of Theoretical and Applied Electronic Commerce Research, 2023 This study investigates the optimal versioning problem when a monopoly software provider bears the deliberation cost to help reduce consumer uncertainty about SaaS customization.
Wenjun Shu +3 more
doaj +1 more source
Jurnal Minds: Manajemen Ide dan Inspirasi, 2023 The telecommunications industry is one of the most competitive industries with high penetration of digital technology, faster availability of data services, and innovations in telecommunications. The purpose of the present study is to empirically test a model that illustrates how customer relationship marketing (CRM) and customer bonding (CBD) affect ...
Haris Maupa +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Assessing Operability on Berthed Ships. Common Approaches, Present and Future Lines
Journal of Marine Science and Engineering, 2020 The revenue of a ship company, a terminal, a port and even the whole logistic chain largely depends on the performance of (un)loading operations inside port areas. However, they are conditioned by met-ocean agents that exert stresses on fixed structures,
Rafael Molina-Sanchez +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Customer retaliation at the employee–customer interface
Journal of Management & Organization, 2008 AbstractThe service encounter is the point where employees and customers interact both positively and negatively. When things go wrong (service failure), initially it is the employee who is required to remedy the situation (recover the service). While positive service recovery outcomes are well investigated, there is little research that investigates ...
Keeffe, Dominique A. +2 more
openaire +4 more sources