Results 71 to 80 of about 15,623 (252)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Pricing Strategy and Blockchain-Enabled Data Sharing in Cross-Border Port Systems

Mathematics
The study examines the impact of pricing strategies on the competition and cooperation of cross-border ports, focusing on unified pricing and differential pricing.
Huida Zhao, Chanjuan Liu
doaj   +1 more source

TEAMWORK IN THE CUSTOMS ADMINISTRATION

Teamwork is a formal organizational approach that aligns the predefined goals and tasks of the Customs Administration with its overarching mission. As a work arrangement, teamwork fosters a collaborative environment, generates positive energy, and enhances organizational performance – particularly in terms of productivity and efficiency among customs ...
openaire   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Water resource forecasting with machine learning and deep learning: A scientometric analysis

Artificial Intelligence in Geosciences
Water prediction plays a crucial role in modern-day water resource management, encompassing both hydrological patterns and demand forecasts. To gain insights into its current focus, status, and emerging themes, this study analyzed 876 articles published ...
Chanjuan Liu, Jing Xu, Xi’an Li, Zhongyao Yu, Jinran Wu   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Benefits and Vulnerabilities of the Free Trade Agreement for the EAEU Countries and China

Евразийская интеграция: экономика, право, политика
Aim. Objective is to formulate the position of the EAEU in the negotiations on the free trade area with China.Tasks. We determine the potential results of the creation of the China-EAEU free trade area for each country.Methods.
W. Xintaoa, E. V. Zhiryaeva, Zh. Leting
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Influential factors of residents’ online green behavior in China: the mediating role of social trust

Scientific Reports
Environmental issues are associated with the pursuit of sustainable development in human society. To address environmental challenges, it is crucial to encourage residents to engage in pro-environmental behaviors.
Yong Li, Xiao Yu, Ranran Wang
doaj   +1 more source