Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Cultural and Social Determinants of Physical Therapy Rehabilitation in Saudi Arabia: A Narrative Review. [PDF]
Healthcare (Basel)Alonazi A.
europepmc +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
The Many Faces of Indeterminacy in Interactive Deadbots. [PDF]
Philos TechnolKozlovski A, Harbinja E, Dobbe R.
europepmc +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Perceived causes and contributory conditions for perinatal death: perspectives of midwives, parents, and communities in Northwest Ethiopia-a qualitative study. [PDF]
Front Med (Lausanne)Arega DT, Gobena T, Assefa N, Tura AK.
europepmc +1 more source
The European Common Market and the General Agreement on Tariffs and Trade: A Study in Compatability [PDF]
, 1961 Allen, James Jay
core +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Impact of China's Accession Protocol on its participation in the WTO dispute settlement mechanism: An analysis of eleven cases involving China's Accession Protocol. [PDF]
HeliyonQianyi S.
europepmc +1 more source