Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Price volatility, market regulation and risk management: challenges for the future of the CAP [PDF]
This article provides an analysis of the European Commission’s proposals (18 Novembre 2010) regarding the next CAP reform. It proposes a reflection centered on the volatility of agricultural prices, the market regulation mechanisms and the risk ...
Vincent Chatellier
core +1 more source
An Independent Review of the E.U. Illegal, Unreported, and Unregulated Regulations [PDF]
Illegal, unregulated and unreported (IUU) fishing refers to fishing activities that do not comply with national, regional, or international fisheries conservation or management legislation or measures .
Indrani Lutchman +2 more
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Russia’s foreign economic cooperation in the context of sanctions: new features
Introduction. In the context of unprecedented sanctions pressure on the Russian economy, due to the restraint of economic growth by unfriendly countries, foreign economic cooperation is actively continuing through participation in international ...
Z. O. Adamanova
doaj +1 more source
Uniformity of Application of the EU Customs Law: Problematic Aspects in the Baltic States
Research purpose. The EU Customs Law is a significant branch of the EU substantive law. On the basis of the Union Customs Code (UCC; Regulation [EU] No. 952/2013) and the Combined Nomenclature of the European Union (Regulation [EU] No.
Valantiejus Gediminas, Katuoka Saulius
doaj +1 more source
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Transit: An analysis of networked criminal groups and criminal opportunities at transit ports [PDF]
Like the path of many contraband commodities, trafficked cultural objects cross countless legal borders and intersect with the legitimate market world at a number of critical transit junctures, which supports the concept of a single “grey” market.
Casey, Ryan Nicole
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source

