Results 71 to 80 of about 8,076 (266)
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The Eurasian economic union and legal regulation of integration processes in the post-Soviet space
Нe emergence and establishment of the Eurasian Economic Union, as well as the interaction of the integration process, which made possible the emergence of the Customs Union.
M.K. Nakysheva
doaj
Евразийн интеграцчлал: Гаалийн холбооноос Евразийн эдийн засгийн холбоонд
ОХУ ТУХН-ийн орон зайд Евразийн эдийн засгийн холбоо байгуулах зорилго тавьсанаас хойш 20 гаруй жил болж байна. Энэ хугацаанд Евразийн эдийн засгийн нийгэмлэг, Гаалийн холбоо, Нэгдсэн эдийн засгийн орон зай зэрэг интеграцийн бүлэглэлүүд бий болж, улмаар ...
Нямдолжин А
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The author examines the nature of Russian-German trade in the early years of the German Customs Union and identifies the main trade trends at its initiation.
Mariya I. Diomidova
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
In recent years Polish customs administration has undergone substantial changes not only in its structure but also in terms of tasks execution. Upon Poland’s accession to the European Union the western border was transformed into the internal border ...
Katarzyna Szmyd
doaj
The establishment of German Customs Union: towards the “Customs Union Agreement” of 1833
This article presents an overview of economic situation and trade relations in Germany during the 1815 – 1820s, after the end of the Napoleonic Wars. The customs question was especially urgent due to the disparity of territories, and was being resolved in several German states simultaneously.
openaire +2 more sources

