Results 71 to 80 of about 8,076 (266)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

The Eurasian economic union and legal regulation of integration processes in the post-Soviet space

open access: yesХабаршы. Заң сериясы, 2018
Нe emergence and establishment of the Eurasian Economic Union, as well as the interaction of the integration process, which made possible the emergence of the Customs Union.
M.K. Nakysheva
doaj  

Евразийн интеграцчлал: Гаалийн холбооноос Евразийн эдийн засгийн холбоонд

open access: yesОлон улс судлал, 2014
ОХУ ТУХН-ийн орон зайд Евразийн эдийн засгийн холбоо байгуулах зорилго тавьсанаас хойш 20 гаруй жил болж байна. Энэ хугацаанд Евразийн эдийн засгийн нийгэмлэг, Гаалийн холбоо, Нэгдсэн эдийн засгийн орон зай зэрэг интеграцийн бүлэглэлүүд бий болж, улмаар ...
Нямдолжин А
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Trends in Foreign Trade of Russian Empire and German Customs Union in 1833-1837 through the Business Press

open access: yesRUDN Journal of Russian History
The author examines the nature of Russian-German trade in the early years of the German Customs Union and identifies the main trade trends at its initiation.
Mariya I. Diomidova
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Assessment criteria of Polish customs services effectiveness in customs clearance of foreign trade goods

open access: yesContemporary Economy, 2013
In recent years Polish customs administration has undergone substantial changes not only in its structure but also in terms of tasks execution. Upon Poland’s accession to the European Union the western border was transformed into the internal border ...
Katarzyna Szmyd
doaj  

The establishment of German Customs Union: towards the “Customs Union Agreement” of 1833

open access: yesИсторический журнал: научные исследования, 2020
This article presents an overview of economic situation and trade relations in Germany during the 1815 – 1820s, after the end of the Napoleonic Wars. The customs question was especially urgent due to the disparity of territories, and was being resolved in several German states simultaneously.
openaire   +2 more sources

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