Results 131 to 140 of about 615,808 (305)

A fuzzy multi-objective model for a project management problem [PDF]

Iranian Journal of Optimization, 2017
In this research, the multi-objective project management decision problem with fuzzy goals and fuzzy constraints are considered. We constitute α-cut approach and two various fuzzy goal programming solution methods for solving the Multi-Objective Project ...
S.M. Mirmohseni, S.H Nasseri
doaj  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Cut-and-Project Tilings Constructed From Crystallographic Tilings. [PDF]

, 2016
An important method to construct aperiodic tilings is the method of canonical projection from higher dimensional lattices. Lattices are the orbits of special type of crystallographic groups. For example, Penrose tilings can be obtained from a lattice tiling of E5, by the cut-and project method.
openaire   +2 more sources

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Development of head sample of the slug squeezing system on blooming setup of MNLZ of Belarussian metallurgical works

Литьë и металлургия, 2003
On the basis of mathematical modeling there are analyzed the different variants of placement of equipment and technology of blooms soft squeezing at casting of them at MNLZ-3 RUP ''Belarussian metallurgical works''.
V. A. Matochkin, A. V. Steblov, Ju. M. Aizin, A. V. Kuklev, A. M. Toptygin, V. V. Tinjakov   +5 more
doaj  

International architectural workshop Patching the City 2011 [PDF]

AR: Arhitektura, Raziskave, 2012
The city of Rijeka is cut off from the sea by a strip of abandoned industrial zones. With the revitalisation of the degraded industrial areas, the city has an opportunity to progress and regain contact with the sea.
Vasa J. Perović, Anja Vidic
doaj  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

A cut-and-project perspective for linearized Bregman iterations

The linearized Bregman iterations (LBreI) and its variants are powerful tools for finding sparse or low-rank solutions to underdetermined linear systems. In this study, we propose a cut-and-project perspective for the linearized Bregman method via a bilevel optimization formulation, along with a new unified algorithmic framework.
Dai, Yu-Hong, Deng, Kangkang, Zhang, Hui
openaire   +2 more sources