Results 81 to 90 of about 615,808 (305)

Material management comparison between lot for lot and field actual condition [PDF]

E3S Web of Conferences
Project material management aims to regulate effective and efficient use materials because material is a resource the largest percentage of the total project cost.
Atmaja Jajang, Natalia Monika, Masrilayanti, Ramadhani Siraj, Rahmadini Yessa, Sourkan Sulleyman   +5 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Influence of Metro Shield Left/Right Line Tunnel Parallel Under-passing on the Defor-mation and Stress of Existing Open-cut Highway Tunnel under Deformation Joint Working Condition

Chengshi guidao jiaotong yanjiu
Objective To ensure the successful implementation of metro shield tunnel parallel under-passing through the existing open-cut highway tunnel project under deformation joint condition, it is necessary to analyze the deformation situation and stress ...
ZHANG Liangliang, SUN Qianhui, FU Jinyang, SUN Wenhao, LI Yanan, LIU Ren, YANG Zhou   +6 more
doaj   +1 more source

Establishing Control Limits on Time Performance Indicators of Projects through Monte Carlo Simulation and Earned Duration Management [PDF]

فرایند مدیریت و توسعه, 2019
Earned Duration Management (EDM) method has been developed to enhance Earned Value Management and to solve some of its problems, such as separation of measuring time and cost dimensions.
Akbar Alam-Tabriz, Farnoosh Khaledian, Mostafa Mahdipour   +2 more
doaj  

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

A project management framework for enhanced productivity performance using building information modelling

Construction Economics and Building, 2017
Although the Singapore government has mandated submissions of building plans in building information modelling (BIM) format since July 2013, this does not yet seem to lead to enhanced productivity performance.
Longhui Liao, Evelyn Ai Lin Teo, Sui Pheng Low   +2 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Affine extension of noncrystallographic Coxeter groups and quasicrystals

, 2002
Unique affine extensions $H^{\aff}_2$, $H^{\aff}_3$ and $H^{\aff}_4$ are determined for the noncrystallographic Coxeter groups $H_2$, $H_3$ and $H_4$. They are used for the construction of new mathematical models for quasicrystal fragments with 10-fold ...
Brodsky M H, Bul'enkov N A, Champagne B, Chen L, Coxeter H S M, DiVincenzo D P, Elser V, Fradkin M A, Humphreys J E, Janot C, Jirí Patera, Kac V, Kass S, Kroto H W, Masáková Z, Masáková Z, Masáková Z, Masáková Z, Moody R V, Moody R V, Moody R V, Patera C S L J, Patera J, Reidun Twarock, Scherbak O P, Zuber J B, Zuber J B   +26 more
core   +1 more source