Results 201 to 210 of about 2,634,047 (302)

IκBζ target genes in chronic lymphocytic leukemia. [PDF]

iScience
Sana I, Meloni M, Genova F, Mantione ME, Tascini AS, Zapparoli E, Carbone Faccin G, Paschaloudi D, Del Nero M, Lenzi C, Ranghetti P, Perotta E, Scarfò L, Ghia P, Muzio M.   +14 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Debating the Delphi View of Dyslexia: A Response to Metsala, Morsanyi and Colleagues. [PDF]

Dyslexia
Carroll JM, Holden C, Kirby P, Snowling MJ, Thompson PA.   +4 more
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Supplementary value of primary tumor volume for prognostic stratification in patients with T3-4 nasopharyngeal carcinoma: A retrospective cohort study. [PDF]

Oncol Lett
Huang H, Lu Y, Ouyang Y, Pan M, Tang X, He H, Zhang T, Gong Q, Chen C, Chen Q.   +9 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

To Cut or Not to Cut, That Is the Question [PDF]

Mayo Clinic Proceedings, 1994
openaire   +1 more source

Utility of the Heart-to-Single Vertebra Ratio Compared with Artificial Intelligence-Derived Vertebral Heart Score for Detecting Cardiomegaly in Dogs with Myxomatous Mitral Valve Degeneration. [PDF]

Vet Sci
Güder BE, Kot ZN, Szatmári V.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source