Results 61 to 70 of about 791,464 (334)

Beyond CD30: Dual‐Targeting of Malignant and Regulatory T Cells by Brentuximab Vedotin Remodels the Lymphoma Microenvironment and Overcomes Resistance via BCL2 Inhibition in Mycosis Fungoides

Advanced Science, EarlyView.
Single‐cell RNA analyses of paired lesions from CD30+ mycosis fungoides patients demonstrate that brentuximab vedotin (BV) induces immunogenic cell death in both CD30+ and CD30− malignant T cells. BV also targets regulatory T cells and remodels tumor microenvironment, while resistance is driven by impaired IFN responses, drug efflux, and BCL2 ...
Yi Jiang, Pan Lai, Mingjia Li, Yujie Wen, Mengzhou Cao, Yu Xiao, Zhuojing Chen, Jingru Sun, Yang Wang   +8 more
wiley   +1 more source

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified (DLBCL NOS) Presenting as Multiple Subcutaneous Nodules: An Unusual Cutaneous Presentation of Systemic Disease

Case Reports in Pathology, 2023
Diffuse large B-cell lymphoma, not otherwise specified (DLBCL NOS) is the most common lymphoid malignancy in the Western world and classically presents as a rapidly enlarging nodal or extranodal mass.
Nika Tavberidze, Daniel D. Bennett, Daniel R. Matson   +2 more
doaj   +1 more source

The Incidence of Other Primary Cancers in Patients with Cutaneous Lymphoma

Annals of Dermatology, 2018
Background Skin cancer is the most common other primary cancer in patients with lymphoma. However, an intriguing association between cutaneous lymphoma and other primary cancers has been suggested in a few studies. Objective This study investigated other
Y. J. Kim, H. Shin, C. Won, S. Chang, M. Lee, Jee-Ho Choi, W. Lee   +6 more
semanticscholar   +1 more source

Molluscum contagiosum infection with features of primary cutaneous anaplastic large cell lymphoma [PDF]

, 2019
CD30+ T cell pseudolymphomas (CD30+ PSL) are a group of benign inflammatory cutaneous disorders that can develop in settings of viral infections or drug reactions.
Lee, Jason B, Nikbakht, Neda, Ringe, John, Shalabi, Doaa   +3 more
core   +1 more source

Somatostatin receptor scintigraphy in cutaneous malignant lymphomas [PDF]

, 1996
Background: Lymphoid cells may express somatostatin receptors (SS-Rs) on their cell surface. Therefore radiolabeled somatostalin analogues may be used to visualize SS-R-positive lymphoid neoplasms in vivo.
Anker-Lugtenburg, P.J. (P.) van den, Heule, F. (Freerk), Joost, Th. (Theo) van, Krenning, E.P. (Eric), Löwenberg, B. (Bob), Oei, H.Y. (H.), Vanhagen, P.M. (P.)   +6 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

A case report of primary cutaneous marginal zone B-cell lymphoma with mastocytosis

SAGE Open Medical Case Reports, 2021
A 53-year-old man presented with asymptomatic, dusky reddish nodules on his trunk, which had persisted for 7 years. Histological findings showed nodular to diffuse dermal infiltration of lymphocytes with irregular nuclei, eosinophils, plasma cells, and ...
Hyun Yi Lee, Joong Sun Lee, Dae Won Koo
doaj   +1 more source

Diagnosis of cutaneous T-cell lymphoma by insurance type before and after the Affordable Care Act: a national database study [PDF]

, 2019
The Affordable Care Act (ACT) was implemented to increase health care access and reduce the uninsured in the age group between pediatric and Medicare populations (18-64). The association of the ACA with insurance type upon diagnosis (uninsured, Medicaid,
Duvic, Madeleine, Park, Katherine E, Ramachandran, Vignesh, Shah, Jesal R   +3 more
core  

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Cobomarsen, an oligonucleotide inhibitor of miR‐155, co‐ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T‐cell lymphoma

British Journal of Haematology, 2018
miR‐155, a microRNA associated with poor prognosis in lymphoma and leukaemia, has been implicated in the progression of mycosis fungoides (MF), the most common form of cutaneous T‐cell lymphoma (CTCL).
A. Seto, Xuan Beatty, J. M. Lynch, M. Hermreck, M. Tetzlaff, M. Duvic, A. Jackson   +6 more
semanticscholar   +1 more source