Results 251 to 260 of about 757,323 (338)
ABSTRACT Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma that typically arises in sun‐exposed skin of older or immunosuppressed patients. Combined or collision tumors involving MCC and other cutaneous malignancies are uncommon, and tumors exhibiting more than two distinct malignant phenotypes are exceptionally rare.
Zeinab Khalil +2 more
wiley +1 more source
Dermatologic Toxicities Associated With Novel Pan‐RAS/RAF Inhibitors
ABSTRACT Background The mitogen‐activated protein kinase (MAPK) pathway plays a key role in cell‐cycle regulation and tumor progression in cancer. Dermatologic toxicities (DTs) to newer pan‐RAS (RMC‐6236) and pan‐RAF (LXH254/naporafenib) inhibitors are emerging.
Lin J. He +11 more
wiley +1 more source
Clinical outcomes of intratumoural para‐toluenesulfonamide treatment in equine melanoma
Summary Equine melanoma is one of the most common cutaneous neoplasms in horses and is particularly prevalent in grey horses. Although these tumours often demonstrate indolent biological behaviour, some progressively develop locally invasive or malignant characteristics over time, making treatment decisions challenging in clinical practice.
H.‐C. Lo +4 more
wiley +1 more source
This review provides an update on the epidemiology, pathogenesis, and clinical/histologic features of cutaneous leiomyosarcoma. Prognostic factors (e.g., depth of tumor involvement, grade, etc.) that can facilitate risk stratification are also discussed, as are treatment approaches for this rare malignancy.
Tejas P. Joshi +4 more
wiley +1 more source
Integrated dermoscopy and reflectance confocal microscopy (RCM) enabled real‐world lesion stratification, demonstrated significant diagnostic concordance, and supported melanoma detection and management in a tertiary referral cohort. ABSTRACT Background Accurate non‐invasive assessment of cutaneous lesions requires integration of diagnostic information
Luca Ambrosio +10 more
wiley +1 more source
Implementation of Total Body Photography for Skin Cancer Early Detection: A Systematic Review
This review maps the use of total body photography (TBP) for skin cancer early detection and prevention. It highlights the evolving TBP technologies used, personnel performing imaging, and potential care models employed. Despite this evolution, workflow processes remain broadly consistent, though variably sequenced across settings. ABSTRACT Advances in
Nurul Amanina Binte Hussain +6 more
wiley +1 more source
ABSTRACT Melanistic lesions, including non‐raised black areas due to proliferations of melanocytes and melanomacrophages in the dermis and epidermis, as well as raised black areas consistent with melanoma, are described in brown bullhead (BBH) Ameiurus nebulosus from three water bodies in the northeastern United States and Quebec, Canada.
Vicki S. Blazer +9 more
wiley +1 more source
Allele‐Specific GNAQ Q209 Mutations Reveal Context‐Dependent Oncogenic Programs in Uveal Melanoma
Using matched immune‐competent, multistep uveal melanoma models, we show that GNAQ Q209L and Q209R mutations are not functionally equivalent. Q209L drives faster in vivo progression but reduces in vitro proliferation and migration, whereas Q209R promotes greater in vitro fitness and preferential FAK‐YAP activation, revealing an allele‐dependent ...
Vinesh Jarajapu +5 more
wiley +1 more source

