Results 51 to 60 of about 99,788 (345)

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Diagnostic challenge for ovarian malignant melanoma in premenopausal women: Primary or metastatic?

World Journal of Surgical Oncology, 2011
Background In the ovary, metastatic malignant melanoma may be confused with primary malignant melanoma and presents a diagnosis challenge. Most cases are associated with disseminated diseases and poor prognosis.
Kharmoum Saoussan, Essaidi Ismail, Oukabli Mohamed, Kadiri Habiba, Fadoukhair Zouhour, Sbitti Yassir, M'rabti Hind, Albouzidi Abderrahmane, Ichou Mohammed, Errihani Hassan   +9 more
doaj   +1 more source

Melanoma mimicking malignant peripheral nerve sheath tumor with spread to the cerebellopontine angle: Utility of next-generation sequencing in diagnosis [PDF]

, 2018
Cutaneous spindle cell malignancy is associated with a broad differential diagnosis, particularly in the absence of a known primary melanocytic lesion.
Birinyi, Paul, Chernock, Rebecca, Coppens, Jeroen, Hanson, Katie Fox, Raptis, Constantine, Schwetye, Katherine E., Walker, Ronald   +6 more
core   +3 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Primary Malignant Melanoma of the Stomach: A Rare Entity

Archives of Medicine and Health Sciences, 2021
Primary gastrointestinal malignant melanoma is an unusual clinical entity. With primary gastric melanoma being very rare, Primary gastric melanoma is underdiagnosed as clinical manifestations are not specific and usually similar with other common ...
Sarita Asotra, Akshita Mehta, Brij Sharma   +2 more
doaj   +1 more source

MicroRNAs in melanoma development and resistance to target therapy [PDF]

, 2017
microRNAs constitute a complex class of pleiotropic post-transcriptional regulators of gene expression involved in the control of several physiologic and pathologic processes.
Ascierto, Paolo Antonio, Ciliberto, Gennaro, Costantini, Susan, Croce, Carlo M, Fattore, Luigi, Malpicci, Debora, Mancini, Rita, Ruggiero, Ciro Francesco   +7 more
core   +1 more source

Genetics of Cutaneous Malignant Melanoma

Cancer Control, 1995
An increase in the clinical significance of cutaneous malignant melanoma has paralleled a dramatic increase in the rate of death from this disease. The critical genetic changes associated with the genesis and progression of this disease are only beginning to be identified.
, Su, , Trent
openaire   +2 more sources

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Recurrent malignant melanoma presenting as multiple bilateral breast masses: A case report

Radiology Case Reports, 2020
Malignant melanoma is a tumor that originates from melanocytes. Melanoma commonly metastasizes to the lungs, brain, or any other solid organ. Herein, we describe the case of a 69-year-old woman with a previous history of cutaneous melanoma who presented ...
Royale Lim, BSc
doaj   +1 more source

Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival [PDF]

, 2017
LDL receptor-related proteins (LRPs) are transmembrane receptors involved in endocytosis, cell-signaling, and trafficking of other cellular proteins. Considerable work has focused on LRPs in the fields of vascular biology and neurobiology.
Gilder, Andrew S., Gonias, Steven L., Karimi-Mostowfi, Nicki, Mantuano, Elisabetta, Murray, Sarah S.   +4 more
core   +3 more sources