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Kindlin-1 loss disrupts vascular and extracellular matrix organisation to sustain hypoxia in cutaneous squamous cell carcinoma

Hardman D, Carrasco G, Lee M, Furqan M, Enjalbert R, Brunton V, Bernabeu M.   +6 more
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Cutaneous Squamous Cell Carcinoma

Hematology/Oncology Clinics of North America, 2019
Cutaneous squamous cell carcinoma represents 20% of all skin cancers, resulting in 1 million cases in the United States each year. The lifetime risk of developing squamous cell carcinoma continues to increase annually and will likely continue to increase because of the aging population. Most cutaneous squamous cell carcinoma are treated locally, with a
Chrysalyne Schmults
exaly   +3 more sources

Cutaneous Squamous Cell Carcinoma

Clinics in Laboratory Medicine, 2017
Cutaneous squamous cell carcinoma (cSCC) is a malignant neoplasm of the skin characterized by an aberrant proliferation of keratinocytes. Cutaneous SCC is the second most common malignancy globally, and usually arises in the chronically sun-damaged skin of elderly white individuals.
Vishwas, Parekh, John T, Seykora
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Advances in cutaneous squamous cell carcinoma

Nature Reviews Cancer, 2023
Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise transformation from healthy epithelium to premalignant dysplasia to invasive neoplasia involves sequential dysregulation of biological networks that govern essential functions of epithelial homeostasis.
Mårten C. G. Winge, Laura N. Kellman, Konnie Guo, Jean Y. Tang, Susan M. Swetter, Sumaira Z. Aasi, Kavita Y. Sarin, Anne Lynn S. Chang, Paul A. Khavari   +8 more
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Cutaneous Squamous Cell Carcinoma

Advances in Dermatology, 2008
Cutaneous SCC is the second most common skin cancer among whites. Most cases of primary cutaneous SCC are induced by UV radiation. Chronic sun exposure is the major risk factor, and favored locations include the head and neck and other sun-exposed areas.
Jorge, Garcia-Zuazaga, Suzanne M, Olbricht   +1 more
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Cutaneous squamous cell carcinoma in a child

Journal of Plastic, Reconstructive & Aesthetic Surgery, 2009
Cutaneous squamous cell carcinoma in children is very rare. Of those reported cases, most arise in the context of underlying predisposing conditions such as xeroderma pigmentosum, albinism or immunosuppression. We report a rare case of cutaneous squamous cell carcinoma in a child with no history of predisposing conditions.
A, Kotwal, D, Watt
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Facial cutaneous squamous cell carcinoma

BMJ, 2016
#### What you need to know Skin cancers account for almost half of all referrals to dermatology, and with an increasingly ageing population, in the United Kingdom non-melanoma skin cancers have been predicted to increase by 50% by 2030.1 Cutaneous squamous cell carcinoma (cSCC) is the second most common type of non-melanoma skin cancer after basal ...
Arif M, Aslam, Anand N, Patel
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Biology of cutaneous squamous cell carcinoma

Journal of the American Academy of Dermatology, 1992
Nonmelanoma skin cancer is the leading cause of cancer in the United States. Cutaneous squamous cell carcinoma is second only to basal cell carcinoma in prevalence and its incidence is increasing. The biology of squamous cell carcinoma is reviewed under the broad areas of etiology, immunobiology, biochemistry, metastatic potential, and therapy, with ...
R E, Kwa, K, Campana, R L, Moy
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Pachydermoperiostosis with cutaneous squamous cell carcinomas

International Journal of Dermatology, 1998
A 46‐year‐old man visited our department with masses on the face and a skin problem. Approximately 15 years ago, he had noticed marked thickening of the skin on the face and scalp, which had exaggerated progressively to produce deep wrinklings with seborrhea (Fig. 1).
S C, Lee, H J, Moon, D, Cho, D W, Ryang, S J, Kim, I K, Chun, Y H, Won   +6 more
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Cutaneous squamous cell carcinoma and hypercalcemia

Journal of the American Academy of Dermatology, 1987
An elderly man was admitted to the hospital with a large squamous cell carcinoma involving the right side of the chest wall. The patient was severely confused, and evaluation revealed pronounced hypercalcemia. With total surgical removal of the tumor, the serum calcium level fell to normal and his confusion cleared.
D D, Picascia, W A, Caro
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