Results 71 to 80 of about 2,361,401 (358)

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

open access: yesFEBS Letters, EarlyView.
We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio   +9 more
wiley   +1 more source

Refrigerated cutting tools improve machining of superalloys [PDF]

open access: yes, 1971
Freon-12 applied to tool cutting edge evaporates quickly, leaves no residue, and permits higher cutting rate than with conventional coolants.
Dudley, G. M.
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Estimation the wear state of milling tools using a combined ensemble empirical mode decomposition and support vector machine method

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
Vibrational signals resulting from tool wear have non-linear and non-stationary features. It is also difficult to acquire large numbers of typically worn samples in practice.
Chuangwen XU   +3 more
doaj   +1 more source

Comprehension of chip formation in laser assisted machining [PDF]

open access: yes, 2011
Laser Assisted Machining (LAM) improves the machinability of materials by locally heating the workpiece just prior to cutting. Experimental investigations have confirmed that the cutting force can be decreased, by as much as 40%, for various materials ...
DAL SANTO, Philippe   +2 more
core   +3 more sources

On Packing T-Cuts

open access: yesJournal of Combinatorial Theory, Series B, 1994
A graft \((G,T)\) is a pair consisting of a connected undirected graph \(G= (V,E)\) and a subset \(T\) of \(V\) of even cardinality. A subset \(J\) of \(E\) is a \(T\)-join if \(d_ J(v)\) is odd iff \(v\in T\). A cut \((X,V\backslash X)\) is a \(T\)-cut if \(| X\cap T|\) is odd. For an edge \(e= vw\), the elementary \(T\)-contraction is a graft \((G',T'
András Frank, Zoltán Szigeti
openaire   +3 more sources

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Microtonal Analysis of "Blue Notes" and the Blues Scale

open access: yesEmpirical Musicology Review, 2019
Microtonal evaluation of blue notes in the early blues scale by empirical pitch measurement and statistical characterization has not yet been performed in existing research.
Court B Cutting
doaj   +1 more source

Investigation of target erosion profiles sputter-eroded by a low-energy broad ion beam

open access: yesAIP Advances, 2021
The demand for ion beam sputtering (IBS) coated substrates is growing. In order to find new fields of application for IBS coating technology, it is necessary to understand in detail the distributions of the involved particles in an industrial-scale ...
Wjatscheslaw Sakiew   +2 more
doaj   +1 more source

Investigation of tool geometry effect and penetration strategies on cutting forces during thread milling [PDF]

open access: yes, 2014
The application of thread milling is increasing in industry because of its inherent advantages over other thread cutting techniques. The objective of this study is to investigate the effect of milling cutter tool geometry on cutting forces during thread ...
BRENDLEN, Romain   +3 more
core   +3 more sources

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