Results 81 to 90 of about 2,352,273 (309)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Investigating the CO2 laser cutting parameters of MDF wood composite material [PDF]
, 2011 Laser cutting of medium density fibreboard (MDF) is a complicated process and the selection of the process parameters combinations is essential to get the highest quality of the cut section.
A.G. Olabi +18 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Microtonal Analysis of "Blue Notes" and the Blues Scale
Empirical Musicology Review, 2019 Microtonal evaluation of blue notes in the early blues scale by empirical pitch measurement and statistical characterization has not yet been performed in existing research.
Court B Cutting
doaj +1 more source
Multi-scale simulation of the nano-metric cutting process [PDF]
, 2009 Molecular dynamics (MD) simulation and the finite element (FE) method are two popular numerical techniques for the simulation of machining processes. The two methods have their own strengths and limitations.
A Simoneau +17 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
PARTICULARS OF ADSORBENT REGENERATION WITH THE USE OF MICROWAVE ENERGY
Acta Polytechnica, 2019 Energy conservation issues are acute in the world. Compressed air is widely used in the modern industrial production. The production of compressed air is a very energy-intensive process, since most of the energy, which is expended by the compressor ...
Sergey Dobrotvorskiy +3 more
doaj +1 more source
Refrigerated cutting tools improve machining of superalloys [PDF]
, 1971 Freon-12 applied to tool cutting edge evaporates quickly, leaves no residue, and permits higher cutting rate than with conventional coolants.
Dudley, G. M.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source