Results 71 to 80 of about 763,744 (316)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Cutting parameter-tool material interaction on PcBN tool wear behaviour in ductile iron machining
Scientific ReportsIn response to the increasing requirements for the processing quality and precision of ductile iron parts under the trend of automotive lightweighting and emission reduction, this study systematically investigated the wear behavior and cutting parameter ...
Pengfei Wang +4 more
doaj +1 more source
Psychopathology and philosopy in relation to the existence of human being
, 2018 The analysis of mental disorders necessarily requires careful and multilayered reflection. Psychiatry is indeed focused on complex phenomena and symptoms that can be only partly traced back to merely quantitative objectifiable data.
guido cusinato, john cutting
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018 Vibrational signals resulting from tool wear have non-linear and non-stationary features. It is also difficult to acquire large numbers of typically worn samples in practice.
Chuangwen XU +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Evalaution and optimization of laser cutting parameters for plywood materials [PDF]
, 2013 Laser process parameters influence greatly the width of kerfs and quality of the cut edges. This article reports experiments on the laser plywood-cutting performance of a CW 1.5 kW CO2¬ Rofin laser, based on design of experiments (DOE).
Alrashed, K. +6 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Modelling flan wear of carbide tool insert in metal cutting
, 2005 In this paper theoretical and experimental studies are carried out to investigate the intrinsic relationship between tool flank wear and operational conditions in metal cutting processes using carbide cutting inserts.Anewflank wear rate model, which ...
Liu, X +7 more
core +1 more source