Results 101 to 110 of about 1,424,201 (360)
Analytical models for high performance milling. Part I: cutting forces, structural deformations and tolerance integrity [PDF]
, 2006 Milling is one of the most common manufacturing processes in industry. Despite recent advances in machining technology, productivity in milling is usually reduced due to the process limitations such as high cutting forces and stability.
Budak, Erhan
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Effects of cutting conditions on the cutting forces in machining additively manufactured Ti6Al4V alloy [PDF]
MATEC Web of ConferencesMachining of additive manufacturing (AM) process results in excessive consumption of the cutting power due to the high strength and hardness of the material produced that led to high cutting forces and short tool life during machining process. This paper
Mohammed Sambo Abdulkadir +2 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Investigation on Stone Machining Performance Using Force and Specific Energy
Advances in Mechanical Engineering, 2009 Cutting force and energy are often used as parameters for monitoring the stone cutting process. Empirical models are required to guide the selection of the cutting conditions.
S. Turchetta +2 more
doaj +1 more source
Optimization of 5-axis milling processes using process models [PDF]
, 2006 Productivity and part quality are extremely important for all machining operations, but particularly for 5-axis milling where the machine tool cost is relatively higher, and most parts have complex geometries and high quality requirements with tight ...
Budak, Erhan +4 more
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
MachinesThis work concerns an experimental investigation dealing with the machinability of 60CrMoV18-5 cold-work tool steel under dry CNC hard turning conditions using a CBN cutting insert.
Nikolaos A. Fountas +3 more
doaj +1 more source