Results 101 to 110 of about 1,349,956 (360)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Optimization of 5-axis milling processes using process models [PDF]

, 2006
Productivity and part quality are extremely important for all machining operations, but particularly for 5-axis milling where the machine tool cost is relatively higher, and most parts have complex geometries and high quality requirements with tight ...
Budak, Erhan, Ozturk, Erdinc, Tunc, L. Taner, Tunç, L. Taner, Öztürk, Erdinç   +4 more
core  

Experimental investigation on micromilling of oxygen-free, high-conductivity copper using tungsten carbide, chemistry vapour deposition and single-crystal diamond micro tools [PDF]

, 2010
Insufficient experimental data from various micro tools limit industrial application of the micromilling process. This paper presents an experimental comparative investigation into micromilling of oxygen-free, high-conductivity copper using tungsten ...
Cheng, K, Huo, D
core   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Development of Thermomechanical Model for the Analysis of Effects of Friction and Cutting Speed on Temperature Distribution around AISI 316L During Orthogonal Machining [PDF]

, 2017
In metal cutting,severe deformation takes place in the vicinity of the cutting edge of the high strain-rate and an increase in temperature is observed. Deformation behaviour of the work material in the primary and secondary zones is highly sensitive to ...
Abiola , Abatan, Agarana, M. C., Ajayi, O. O., Ogbonnaya, Mercy   +3 more
core   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Experimental Investigation and NSGA-III Multi-Criteria Optimization of 60CrMoV18-5 Cold-Work Tool Steel Machinability Under Dry CNC Hard Turning Conditions

Machines
This work concerns an experimental investigation dealing with the machinability of 60CrMoV18-5 cold-work tool steel under dry CNC hard turning conditions using a CBN cutting insert.
Nikolaos A. Fountas, Ioannis G. Papantoniou, Dimitrios E. Manolakos, Nikolaos M. Vaxevanidis   +3 more
doaj   +1 more source

Investigation on Stone Machining Performance Using Force and Specific Energy

Advances in Mechanical Engineering, 2009
Cutting force and energy are often used as parameters for monitoring the stone cutting process. Empirical models are required to guide the selection of the cutting conditions.
S. Turchetta, W. Polini, I. S. Buyuksagis   +2 more
doaj   +1 more source

Effects of cutting conditions on the cutting forces in machining additively manufactured Ti6Al4V alloy [PDF]

MATEC Web of Conferences
Machining of additive manufacturing (AM) process results in excessive consumption of the cutting power due to the high strength and hardness of the material produced that led to high cutting forces and short tool life during machining process. This paper
Mohammed Sambo Abdulkadir, Younas Muhammad, Njuguna James   +2 more
doaj   +1 more source