Results 101 to 110 of about 1,418,495 (362)
Cutting load capacity of end mills with complex geometry [PDF]
, 2001 Cutting load capacity of cemented carbide end mills with high length-to-diameter ratios is determined from critical geometric and loading parameters, including a stress concentration factor (SCF) to account for serrated edges, which is determined by ...
Asamoah-Attiah, S. +2 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A polyhedral approach for the Equitable Coloring Problem [PDF]
, 2011 In this work we study the polytope associated with a 0,1-integer programming formulation for the Equitable Coloring Problem. We find several families of valid inequalities and derive sufficient conditions in order to be facet-defining inequalities.
Bahiense +15 more
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effects of cutting conditions on the cutting forces in machining additively manufactured Ti6Al4V alloy [PDF]
MATEC Web of ConferencesMachining of additive manufacturing (AM) process results in excessive consumption of the cutting power due to the high strength and hardness of the material produced that led to high cutting forces and short tool life during machining process. This paper
Mohammed Sambo Abdulkadir +2 more
doaj +1 more source
Development of Thermomechanical Model for the Analysis of Effects of Friction and Cutting Speed on Temperature Distribution around AISI 316L During Orthogonal Machining [PDF]
, 2017 In metal cutting,severe deformation takes place in the vicinity of the cutting edge of the high strain-rate and an increase in temperature is observed. Deformation behaviour of the work material in the primary and secondary zones is highly sensitive to ...
Abiola , Abatan +3 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Investigation on Stone Machining Performance Using Force and Specific Energy
Advances in Mechanical Engineering, 2009 Cutting force and energy are often used as parameters for monitoring the stone cutting process. Empirical models are required to guide the selection of the cutting conditions.
S. Turchetta +2 more
doaj +1 more source
Chlorophyll a fluorescence as a tool to monitor physiological status in the leaves of Artemisia ordosica under root cutting conditions. [PDF]
Front Plant Sci, 2023 Liu Y, Gong C, Pei W, Fan K, Shen W.
europepmc +1 more source