Results 141 to 150 of about 1,424,201 (360)

Corrosion Resistance and Surface Bioactivity of Ti6Al4V Alloy after Finish Turning under Ecological Cutting Conditions. [PDF]

Materials (Basel), 2021
Leksycki K, Kaczmarek-Pawelska A, Ochał K, Gradzik A, Pimenov DY, Giasin K, Chuchala D, Wojciechowski S.   +7 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A NEURAL NETWORK PREDICTION MODEL FOR SURFACEFINISH IN TURNING PROCESS

Journal of Engineering
This paper presents a neural network based surface finish Prediction model in turning operation . Orthogonal cutting tests were performed on mild steel using H.S.S cutting tool with different cutting parameters cutting speed , feed and nose radius of ...
Bahaa Ibraheem Kazem
doaj   +1 more source

Study of the Effects of Initial Cutting Conditions and Transition Period on Ultimate Tool Life when Machining Inconel 718. [PDF]

Materials (Basel), 2021
Memarianpour M, Niknam SA, Turenne S, Balazinski M.   +3 more
europepmc   +1 more source

Mechanical impact tests of materials in oxygen effects of contamination [PDF]

The effect of contaminants on the mechanical impact sensitivity of Teflon, stainless steel, and aluminum in a high-pressure oxygen environment was investigated. Uncontaminated Teflon did not ignite under the test conditions.
Ordin, P. M.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

GROWTH AND DEVELOPMENT OF APPLE TREES UNDER SOIL AND CLIMATIC CONDITIONS OF BUKHARA DEPENDING ON THE METHOD AND DEGREE OF CUTTING

, 2022
Rustam Yunusov, Atayeva Zamira Alimovna, Burieva Dilorom Isroilovna   +2 more
openalex   +2 more sources

Cutting Conditions of Carbide Insert Drill

Journal of the Korean Society of Manufacturing Process Engineers, 2021
Sung-Yun Choi, Chul-Woong Hwang, Sang-Tae Lee   +2 more
openaire   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source