Results 111 to 120 of about 919,769 (305)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Technoeconomic and thermodynamic aspects of the edge cutting machining optimization

open access: yesAdvanced Engineering Research, 2016
The investigation objective is to develop a calculation method of selecting the optimum cutting speed corresponding to the minimum tool-wear rate. The analysis of the known optimization criteria such as tribological, thermal, energy and thermodynamic ...
Anatoliy A. Ryzhkin   +3 more
doaj   +1 more source

Blade cutting simulation with crack propagation through thin-walled structures via solid-shell finite elements in explicit dynamics [PDF]

open access: yes, 2015
To simulate the crack propagation due to blade cutting of a thin-walled shell structure, we propose a numerical technique based on solid shell finite elements and explicit time integration.
Confalonieri, Federica   +2 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Impacts of elevated CO2 and partial defoliation on mineral element composition in rice

open access: yesFrontiers in Plant Science
IntroductionThis study explores how elevated CO2 concentration may alter the source-sink dynamics in rice by providing additional carbon for photosynthesis, thereby affecting nutrient absorption and distribution.MethodsA free-air CO2 enrichment ...
Bo Gao   +11 more
doaj   +1 more source

A Finite Element Modeling of Orthogonal Cutting

open access: yesEngineering review (Technical Faculty University of Rijeka), 1997
A finite element model of orthogonal metal cutting is described. The proposed model is based on an updated Lagrangian formulation for plane strain conditions and employs an elastic-plastic material model.
openaire   +1 more source

Boundary element method in evaporative laser cutting

open access: yesApplied Mathematical Modelling, 1996
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kim, Meung Jung, Majumdar, Pradip
openaire   +2 more sources

FABRIC: A National-Scale Programmable Experimental Network Infrastructure [PDF]

open access: yes, 2019
FABRIC is a unique national research infrastructure to enable cutting-edge and exploratory research at-scale in networking, cybersecurity, distributed computing and storage systems, machine learning, and science applications.
Baldin, I   +7 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Software Control of Machines Based on Typification of Transient Zone Parameters for Processing of Original Non-Circular Parts

open access: yesМеханика машин, механизмов и материалов
The paper provides an overview of trends in the preparation of control programs for CNC metal cutting machines. The direction in the development of programming of machining parts based on the transient zone parameter typification is described.
Nikolay N. Popok   +2 more
doaj   +1 more source

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