Results 61 to 70 of about 919,769 (305)

Ultra-Precision Cutting and Characterization of Reflective Convex Spherical Blazed Grating Elements

Micromachines, 2022
In this work, based on the diffraction principle of reflective blazed grating, the structure size of the convex spherical blazed grating unit is determined, the machining accuracy of the convex spherical blazed grating is formulated, the effects of tool ...
Huang Li, Xiaoqiang Peng, Chaoliang Guan, Hao Hu   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Crack propagation in thin shells by explicit dynamics solid-shell models [PDF]

, 2013
A computational technique for the simulation of crack propagation due to cutting in thin structures is proposed. The implementation of elastoplastic solid-shell elements in an explicit framework is discussed.
Pagani, Mara, Perego, Umberto
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Влияние демпфирования режущих пластин из поликристаллов КНБ на стойкость резцов [PDF]

, 2010
Досліджено вплив демпфування ріжучих інструментів з використанням вставок з різних матеріалів. Встановлено, що використання нікеліду титану дозволяє знизити шорсткість обробленої поверхні та підвищити стійкість різця.Damping capacities of cutting tool ...
Девин, Л. Н., Деркач, Н. Н., Новиков, Н. В., Осадчий, А. А., Сулима, А. Г.   +4 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Hypoplastic particle finite element model for cutting tool-soil interaction simulations: Numerical analysis and experimental validation

Underground Space, 2018
This study presents numerical and experimental models for the analysis of the excavation of soft soils by means of a cutting tool. The computational model is constructed using an Updated Lagrangean (UL) velocity-based Finite Element approach.
Abdiel Ramon Leon Bal, Ulrich Hoppe, Thai Son Dang, Klaus Hackl, Günther Meschke   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Особенности создания физической модели процесса образования элементов стружки при обработке глубоких отверстий [PDF]

, 1952
The physical model of the process of chip elements' formation, when materials are processing by cutting, is offered. On the basis of offered physical model, it is possible to create the general math-ematical model, which describes the process of cutting ...
Маршуба, Вячеслав Павлович
core   +1 more source