Results 101 to 110 of about 3,023,757 (394)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Investigate the Lubrication Effects on Cutting Force and Power Consumption in Up and Down End Milling [PDF]
, 2013 Milling is a machining process by which a surface is generated by a progressive chip removal. An experimental investigation has been carried out on the performance of up and down milling under dry and flood conditions when end milling medium carbon steel
Mohd Hamdi Abd Shukor, Mohsen Abdelnaeim Hassanim Mohamed +2 more
core
An expert mill cutter and cutting parameters selection system incorporating a control strategy
, 2008 This paper discusses the selection of tools and cutting parameters in milling operations. To carry out this research, an expert system has been developed based on numerical methods of performance evaluation.
De la Sen, Manuel +5 more
core +1 more source
Modeling of cutting force prediction in machining high-volume SiCp/Al composites
Applied Mathematical Modelling, 2019 Variations in cutting forces significantly influence the tool wear and part quality in machining high-volume SiC-particle-reinforced aluminum matrix (SiCp/Al) composites.
Jinfeng Wang +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
A predictive model for the cutting force in wood machining developed using mechanical properties
, 2012 In this study a number of work piece variations were evaluated whilst limiting the cutting conditions. Eight wood species controlled at four moisture levels were machined along and across the wood grain.
Andrew Naylor, +7 more
core
IEEE Access, 2018 Tool condition monitoring systems are essential in micromilling applications. A tool’s slenderness requires high-precision monitoring systems for online measurements.
J. Jauregui +5 more
semanticscholar +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Load Characteristics in the Cutting of Three Types of Bauxite by Conical Picks
Applied SciencesUnderground bauxite comprehensive mechanized mining has attracted growing attention, yet regional differences in bauxite characteristics challenge its applicability and economic efficiency. The conical pick, a key cutting tool for this mining method, has
Weipeng Xu +7 more
doaj +1 more source