Results 91 to 100 of about 3,826,227 (356)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Applied SciencesAiming at the problems of large cutting force, easy honeycomb tearing, and deformation during the traditional cutting process of aramid honeycomb materials and an increase in cutting temperature during continuous processing, which may lead to vibration ...
Mingxing Zhang +6 more
doaj +1 more source
Modeling of cutting force prediction in machining high-volume SiCp/Al composites
Applied Mathematical Modelling, 2019 Variations in cutting forces significantly influence the tool wear and part quality in machining high-volume SiC-particle-reinforced aluminum matrix (SiCp/Al) composites.
Jinfeng Wang +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
IEEE Access, 2018 Tool condition monitoring systems are essential in micromilling applications. A tool’s slenderness requires high-precision monitoring systems for online measurements.
J. Jauregui +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Size Effect in Metal Cutting Force
Journal of the Japan Society of Precision Engineering, 1965 The theoretical consideration of energies consumed in metal cutting and the experimental observations on orthogonal light cutting of 4-6 brass lead to the conclusion that the size effect in cutting force can be explained as follows: with the decrease in depth of cut, the specific cutting force increases because of(1) decrease in magnitude of shear ...
K. Tamura, K. Nakayama
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Metals, 2020 Cutting force in the machining process of SiCp/Al particle reinforced metal matrix composite is affected by several factors. Obtaining an effective mathematical model for the cutting force is challenging.
Rashid Ali Laghari +2 more
doaj +1 more source