Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Design and Study on the Cutting Structure of Rotary Cutting PDC Bit
Shiyou jixie, 2020 The rotary cutting PDC bit can well adapt to deep high-plasticity strata. In this paper, the cutting performance of rotary cutting PDC bit was investigated by means of experiment and simulation.
Cao Yang, Wang Haitao
doaj
Research into mechanical modeling based on characteristics of the fracture mechanics of ice cutting for scientific drilling in polar regions [PDF]
The CryosphereScientific drilling in polar regions plays a crucial role in obtaining ice cores and using them to understand climate change and to study the dynamics of polar ice sheets and their impact on global environmental changes (sea level, ocean current cycle ...
X. Lv +8 more
doaj +1 more source
Modelling the cutting forces in micro-end-milling using a hybrid approach [PDF]
, 2014 This paper presents the development of a cutting force model for the micro-end-milling processes under various cutting conditions using a hybrid approach.
Jing, Xiubing +3 more
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Investigation of tool geometry effect and penetration strategies on cutting forces during thread milling [PDF]
, 2014 The application of thread milling is increasing in industry because of its inherent advantages over other thread cutting techniques. The objective of this study is to investigate the effect of milling cutter tool geometry on cutting forces during thread ...
BRENDLEN, Romain +3 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cutting Force Prediction in Drilling of Titanium Alloy
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012 Cutting force in drilling of Ti-6Al-4V is studied with simulation based on a predictive model. In the force model, three-dimensional chip flow is made by piling up the orthogonal cuttings in the planes containing the cutting velocities and the chip flow ...
Shoichi TAMURA +2 more
doaj +1 more source
Research on abrasive wear dress of CBN honing tool based on single abrasive cutting
Jin'gangshi yu moliao moju gongcheng, 2022 The abrasive wear characteristics of large length to diameter ratio CBN single-pass honing tools during ultrasonic dressing process were studied by single abrasive test with 4Cr13 stainless steel as dressing material.
Changyong YANG +3 more
doaj +1 more source
Hip External Rotator Strength Is Associated With Better Dynamic Control of the Lower Extremity During Landing Tasks [PDF]
, 2016 Hip external rotator strength is associated with better dynamic control of the lower extremity during landing tasks. J Strength Cond Res 30(1): 282–291, 2016—The purpose of this study was to determine the association between hip strength and lower ...
Geiser, Christopher +4 more
core +2 more sources