Results 71 to 80 of about 3,023,757 (394)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Geometrical analysis of thread milling – Part 1: Evaluation of tool angles [PDF]
, 2010 Thread milling is a method which is increasingly used for machining thread. For this operation, a helical interpolation is required. Furthermore, the thread mill is a tool whose geometry is rather complex.
FROMENTIN, Guillaume, POULACHON, Gerard
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Geomechanics and Geophysics for Geo-Energy and Geo-ResourcesUnderstanding the distribution of cutting force provides a foundation for the design and optimization of cutterhead layout. The simulation of rotary cutting with a large cutting radius remains a challenge for laboratory tests.
Long-Chuan Deng +6 more
doaj +1 more source
An investigation on the cutting force of milling Inconel 718
MATEC Web of Conferences, 2018 Inconel alloy has been widely used in industry but is difficult to machine due to its rapid change in cutting force during machining. This paper investigated the cutting force for milling Inconel 718 as conventional force model is unable to handle the ...
Tsai Jhy-Cherng +3 more
doaj +1 more source
An investigation on micro cutting mechanics: Modelling, simulations and experimental case studies [PDF]
, 2014 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University London.Micro cutting is becoming increasingly important since miniature and micro components/products have become more and more demanded in precision ...
Sawangsri, Worapong
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
A Model for Predicting Dynamic Cutting Forces in Sand Mould Milling with Orthogonal Cutting
Chinese Journal of Mechanical Engineering, 2018 Cutting force is one of the research hotspots in direct sand mould milling because the cutting force directly affects the machining quality and tool wear. Unlike metals, sand mould is a heterogeneous discrete deposition material. There is still a lack of
Zhong-De Shan, Fu-Xian Zhu
doaj +1 more source
Investigation of tool geometry effect and penetration strategies on cutting forces during thread milling [PDF]
, 2014 The application of thread milling is increasing in industry because of its inherent advantages over other thread cutting techniques. The objective of this study is to investigate the effect of milling cutter tool geometry on cutting forces during thread ...
Sharma, Vishal S. +4 more
core
Experimental study of coated carbide tools behaviour: application for Ti-5-5-5-3 turning [PDF]
, 2011 The goal of this paper is to study the relation between the input data (conditions and geometry of cut) and answers (wear of tool, forces and cutting temperatures) when machining the Ti-5-5-5-3 alloy treated. This study has shown that the cutting process
Wagner, Vincent +7 more
core +1 more source