Results 61 to 70 of about 5,178,314 (300)
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Analysing the Impact of Cutting Force and Vibration on Surface Roughness in External Cylindrical Grinding of SKH2 Stell [PDF]
, 2023 The surface roughness of a part during external cylindrical grinding is directly impacted by cutting force and vibration, which are intermediate parameters. To improve the quality of finished parts, studying and controlling these parameters is essential.
Nguyen, Linh Tuan +3 more
core +1 more source
Design and Study on the Cutting Structure of Rotary Cutting PDC Bit
Shiyou jixie, 2020 The rotary cutting PDC bit can well adapt to deep high-plasticity strata. In this paper, the cutting performance of rotary cutting PDC bit was investigated by means of experiment and simulation.
Cao Yang, Wang Haitao
doaj
Research into mechanical modeling based on characteristics of the fracture mechanics of ice cutting for scientific drilling in polar regions [PDF]
The CryosphereScientific drilling in polar regions plays a crucial role in obtaining ice cores and using them to understand climate change and to study the dynamics of polar ice sheets and their impact on global environmental changes (sea level, ocean current cycle ...
X. Lv +8 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Cutting Force Prediction in Drilling of Titanium Alloy
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012 Cutting force in drilling of Ti-6Al-4V is studied with simulation based on a predictive model. In the force model, three-dimensional chip flow is made by piling up the orthogonal cuttings in the planes containing the cutting velocities and the chip flow ...
Shoichi TAMURA +2 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A Model for Predicting Dynamic Cutting Forces in Sand Mould Milling with Orthogonal Cutting
Chinese Journal of Mechanical Engineering, 2018 Cutting force is one of the research hotspots in direct sand mould milling because the cutting force directly affects the machining quality and tool wear. Unlike metals, sand mould is a heterogeneous discrete deposition material. There is still a lack of
Zhong-De Shan, Fu-Xian Zhu
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source