Results 41 to 50 of about 93,572 (254)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Geomechanics and Geophysics for Geo-Energy and Geo-ResourcesUnderstanding the distribution of cutting force provides a foundation for the design and optimization of cutterhead layout. The simulation of rotary cutting with a large cutting radius remains a challenge for laboratory tests.
Long-Chuan Deng +6 more
doaj +1 more source
An investigation on the cutting force of milling Inconel 718
MATEC Web of Conferences, 2018 Inconel alloy has been widely used in industry but is difficult to machine due to its rapid change in cutting force during machining. This paper investigated the cutting force for milling Inconel 718 as conventional force model is unable to handle the ...
Tsai Jhy-Cherng +3 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and Study on the Cutting Structure of Rotary Cutting PDC Bit
Shiyou jixie, 2020 The rotary cutting PDC bit can well adapt to deep high-plasticity strata. In this paper, the cutting performance of rotary cutting PDC bit was investigated by means of experiment and simulation.
Cao Yang, Wang Haitao
doaj
Research into mechanical modeling based on characteristics of the fracture mechanics of ice cutting for scientific drilling in polar regions [PDF]
The CryosphereScientific drilling in polar regions plays a crucial role in obtaining ice cores and using them to understand climate change and to study the dynamics of polar ice sheets and their impact on global environmental changes (sea level, ocean current cycle ...
X. Lv +8 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Cutting Force Prediction in Drilling of Titanium Alloy
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012 Cutting force in drilling of Ti-6Al-4V is studied with simulation based on a predictive model. In the force model, three-dimensional chip flow is made by piling up the orthogonal cuttings in the planes containing the cutting velocities and the chip flow ...
Shoichi TAMURA +2 more
doaj +1 more source
Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach
FEBS Letters, EarlyView.The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring +3 more
wiley +1 more source