Results 51 to 60 of about 5,178,314 (300)

Research on PCBN Tool Dry Cutting GCr15

open access: yesMachines, 2018
This paper is based on the theoretical analysis designs of a dry cutting orthogonal test in order to study a phenomenon that the radial force is larger than the main cutting force when a PCBN (polycrystalline cubic boron nitride) tool hard turns GCr15 ...
Qinghua Li   +3 more
doaj   +1 more source

Stochastic modeling of the cutting force in turning processes

open access: yesThe International Journal of Advanced Manufacturing Technology, 2020
The main goal of this study is to introduce a stochastic extension of the already existing cutting force models. It is shown through orthogonal cutting force measurements how stochastic processes based on Gaussian white noise can be used to describe the ...
Gábor Fodor   +2 more
semanticscholar   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

SPH method applied to high speed cutting modelling [PDF]

open access: yes, 2007
The purpose of this study is to introduce a new approach of high speed cutting numerical modelling. A Lagrangian smoothed particle hydrodynamics (SPH)- based model is arried out using the Ls-Dyna software.
J. Limido   +9 more
core   +1 more source

Full-scale test of disc cutter rotary cutting in TBM tunnelling: a case study of Mawan granite in Shenzhen, China

open access: yesGeomechanics and Geophysics for Geo-Energy and Geo-Resources
Understanding the distribution of cutting force provides a foundation for the design and optimization of cutterhead layout. The simulation of rotary cutting with a large cutting radius remains a challenge for laboratory tests.
Long-Chuan Deng   +6 more
doaj   +1 more source

An investigation on the cutting force of milling Inconel 718

open access: yesMATEC Web of Conferences, 2018
Inconel alloy has been widely used in industry but is difficult to machine due to its rapid change in cutting force during machining. This paper investigated the cutting force for milling Inconel 718 as conventional force model is unable to handle the ...
Tsai Jhy-Cherng   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Cutting Forces Prediction in the Dry Slotting of Aluminium Stacks [PDF]

open access: yes, 2014
Cutting forces are one of the inherent phenomena and a very significant indicator of the metal cutting process. The work presented in this paper is an investigation of the prediction of these parameters in slotting processes of UNS A92024-T3 (Al-Cu ...
SALGUERO, Jorge   +4 more
core   +1 more source

On modelling of cutting force and temperature in bone milling

open access: yesJournal of Materials Processing Technology, 2019
Cutting force and temperature are the key factors to be controlled during the orthopaedic surgery which could result in mechanical damage and necrosis of the bone tissue.
Zhirong Liao, D. Axinte, D. Gao
semanticscholar   +1 more source

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