Results 91 to 100 of about 66,719 (305)

Towards cutting force evaluation without cutting tests [PDF]

, 2017
Mechanistic cutting force modelling generally involves coefficients identification from machining tests. In order to develop multi-material cutting force models avoiding identification, several studies have tried to link cutting forces to mechanical ...
S. Campocasso, OUTEIRO, José, S. Bissey-Breton, BISSEY BRETON, Stéphanie, CAMPOCASSO, Sébastien, POULACHON, Gerard, G. Poulachon, J.P. Costes, COSTES, Jean-Philippe, MARTINS DO OUTEIRO, Jose Carlos, Bissey-Breton, Stéphanie, J.C. Outeiro   +11 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

INFLUENCE OF CUTTING INSERTS IN MACHINING Al-Si ALLOY-BASED METAL MATRIX COMPOSITES [PDF]

Proceedings on Engineering Sciences
To better comprehend the machinability studies during MMCs, the effect of cutting tool while machining MMCs, the cutting forces that induce and importantly the influence of cutting tool were carried out.
Sudheer Reddy J , Vikram Kedambadi Vasu
doaj   +1 more source

Predictive Cutting Force Model and Cutting Force Chart for Milling with Cutter Axis Inclination

International Journal of Automation Technology, 2013
A force model for milling with cutter axis inclination is presented. The model predicts the cutting force and chip flow direction. Three-dimensional chip flow is interpreted as a piling up of the orthogonal cuttings in the planes containing the cutting velocities and the chip flow velocities in the inclined coordinate system with a ball end mill.
Takashi Matsumura, Motohiro Shimada, Kazunari Teramoto, Eiji Usui   +3 more
openaire   +1 more source

The Effect of Technique Change on Knee Loads during Sidestep Cutting

, 2007
PURPOSE: To identify the effect of modifying sidestep cutting technique on knee loads and predict what impact such change would have on the risk of noncontact anterior cruciate ligament injury.
Elliott, Bruce C, Dempsey, A.R., Munro, Bridget J., Elliott, B.C., Steele, J.R., Dempsey, Alasdair R, Munro, B.J., Russo, K.A., Elliott, Bruce C., Munro, Bridget J, Steele, Julie R., Lloyd, David G, Russo., Kylie A., Russo, Kylie A, Lloyd, D.G., Lloyd, David G., Steele, Julie R, Dempsey, Alasdair R.   +17 more
core   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

From large-scale to micro machining: a review of force prediction models [PDF]

, 2013
In this paper, a reviewof work performed in the area of force modelling in metal cutting processes is presented. Past and present trends are described and criticised to compare their relevance with current requirements.
FROMENTIN, Guillaume, GERMAIN, Dimitri, Bissey-Breton, Stephanie, BISSEY BRETON, Stéphanie, POULACHON, Gerard   +4 more
core  

Degradation modes and tool wear mechanisms in finish and rough machining of Ti17 Titanium alloy under high-pressure water jet assistance [PDF]

, 2013
This article presents the results of an experimental study on the Ti17 titanium alloy, which was carried out to analyze tool wear and the degradation mechanisms of an uncoated tungsten carbide tool insert. Two machining conditions, roughing and finishing,
GERMAIN, Guénaël, FURET, Benoit, AYED, Yessine, AMMAR, Amine   +3 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A predictive model for the cutting force in wood machining developed using mechanical properties

, 2012
In this study a number of work piece variations were evaluated whilst limiting the cutting conditions. Eight wood species controlled at four moisture levels were machined along and across the wood grain.
Andrew Naylor,, Perera, Noel, Emil Clahr, Noel Perera,, Naylor, Andrew, Hackney, Philip, Phil Hackney,, Clahr, Emil   +7 more
core