Results 71 to 80 of about 1,485,853 (259)

Machinability analysis on helical milling of carbon fiber reinforced polymer

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2015
In the helical milling process, a rotating tool traverses a helical trajectory to generate a hole. In order to investigate the cutting state in helical milling of carbon fiber reinforced polymer(CFRP), experiments were conducted with unidirectional and ...
Haiyan WANG, Xuda QIN, Hao LI
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The Investigation of The Effect of Cryogenic Processed PVD and CVD Coated Cutting Tools on Machinability in Turning on Hastelloy X Super Alloy

Gazi Üniversitesi Fen Bilimleri Dergisi, 2017
Super alloys are alloys which has the resistance of high temperatures. In addition to that, super alloys are widely used in aerospace, aviation industries, also in gas turbines because of their high creep strength and high corrosion resistance.
Gültekin UZUN, Selçuk YAGMUR, İhsan KORKUT, Ulvi ŞEKER   +3 more
doaj  

Simultaneous Clamping and Cutting Force Measurements with Built-In Sensors

Sensors, 2020
The intensity of the clamping force during milling operations is very important, because an excessive clamping force can distort the workpiece, while inadequate clamping causes slippage of the workpiece.
Sina Rezvani, Chang-Ju Kim, Simon S. Park, Jihyun Lee   +3 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Dynamic analysis of runout correction in milling [PDF]

, 2010
Tool runout and its effects is an important area of research within modelling, simulation, and control of milling forces. Tool runout causes tool cutting edges to experience uneven forces during milling.
Guzman Villaseñor, Mario, Perez Garcia, Hilde, Diez Cifuentes, Eduardo, Vizán Idoipe, Antonio   +3 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Geometrical analysis of thread milling – Part 2:Calculation of uncut chip thickness [PDF]

, 2010
Thread milling offers interesting possibilities for machining internal or external threads. This machining technique uses a mill with a triangular profile for metric threads and a helical interpolation strategy.
FROMENTIN, Guillaume, POULACHON, Gerard
core   +1 more source

Measurement of Wood Cutting Forces during Bandsawing Using Piezoelectric Dynamometer

Drvna Industrija, 2016
Optimization of wood cutting conditions can decrease the cutting forces, which directly relates to the energy consumption. The aim of this study was to measure cutting force components in bandsaw processing of green oak and beech wood at 90°-90° cutting ...
Payam Moradpour, Frieder Scholz, Kazem Doosthoseini, Asghar Tarmian   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source