Results 51 to 60 of about 1,485,853 (259)

A predictive model for the cutting force in wood machining developed using mechanical properties [PDF]

open access: yes, 2012
In this study a number of work piece variations were evaluated whilst limiting the cutting conditions. Eight wood species controlled at four moisture levels were machined along and across the wood grain.
Andrew Naylor,   +7 more
core   +1 more source

Determination of Optimum Machining Parameters in Machining Rene 41 Superalloy Depending on Cutting Speed [PDF]

open access: yesE3S Web of Conferences
Rene 41 superalloy developed to withstand severe mechanical stresses and high temperature operation, and are widely used in aircraft and space vehicles, especially nickel-based ones, due to their high corrosion resistance.
Altin Abdullah   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

A new approach of high speed cutting modelling: SPH method [PDF]

open access: yes, 2006
The purpose of this study is to introduce a new approach of high speed cutting numerical modelling. A lagrangian Smoothed Particle Hydrodynamics (SPH) based model is carried out using the Ls-Dyna software.
J. Limido   +7 more
core   +1 more source

The effect of cutting conditions, insert coating type, and cooling on cutting forces during face finish milling of high-strength spheroidal grade cast iron

open access: yesТехнічна інженерія
This article presents the results of an experimental study of cutting forces during face finishing of high-strength spheroidal graphite cast iron EN-GJS-600-3 using a Sandvik Coromant R200-051Q22-12H face milling cutter with round carbide inserts ...
S.I. Radkevych, V.M. Ruban
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Experimental study of coated carbide tools behaviour: application for Ti-5-5-5-3 turning [PDF]

open access: yes, 2011
The goal of this paper is to study the relation between the input data (conditions and geometry of cut) and answers (wear of tool, forces and cutting temperatures) when machining the Ti-5-5-5-3 alloy treated. This study has shown that the cutting process
Wagner, Vincent   +7 more
core   +1 more source

Finite Element Analysis of Orthogonal Cutting Forces in Machining AISI 1020 Steel Using a Carbide Tip Tool

open access: yesЖурнал інженерних наук, 2018
Force modeling in metal cutting is important for various purposes, including thermal analysis, tool life estimation, chatter prediction, and tool condition monitoring.
Bashistakumar M., Pushkal B.
doaj   +1 more source

Artificial Neural Network System for Predicting Cutting Forces in Helical-End Milling of Laser-Deposited Metal Materials

open access: yesTehnički Glasnik, 2023
When machining difficult-to-cut metal materials often used to make sheet metal forming tools, excessive cutting force jumps often break the cutting edge. Therefore, this research developed a system of three neural network models to accurately predict the
Uroš Župerl, Miha Kovačič
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

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