Results 71 to 80 of about 1,450,593 (288)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

THE INFLUENCE OF THE FUNCTIONAL GEOMETRY OF THE CUTTING TOOLON THE MAINCUTTINGFORCE IN THE STRING OPERATION [PDF]

Analele Universităţii "Constantin Brâncuşi" din Târgu Jiu: Seria Inginerie, 2018
he quality of the machined parts is strongly influenced by the rigidity of the technological system, but also by the size and variation of the forces that occur during the cutting process.
D. Dobrotă, M. Tomescu
doaj  

Analysis of Indirect Measurement of Cutting Forces Turning Metal Cylindrical Shells [PDF]

, 2014
Cutting forces measurement is an important component of the ma- chining processes development and control. The use of conventional direct meas- urement systems is often impossible as they interfere in the process’s dynamics.
Kirill Kondratenko, GUSKOV, Mikhail, Mikhail Guskov, GOUSKOV, Alexandre, PANOVKO, Grigory, Philippe Lorong, Grigory Panovko, LORONG, Philippe, KONDRATENKO, Kirill, GOUSKOV, Alexander, Alexandre Gouskov   +10 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effect of cryogenic treatment of tungsten carbide tools on cutting force and power consumption in CNC milling process

Production and Manufacturing Research: An Open Access Journal, 2018
In this paper, the effect of Deep Cryogenic Treatment (DCT) soaking duration on tungsten carbide end mill cutters on cutting forces and power consumption during machining P20 mold steel in CNC milling machine is investigated and optimized the process ...
Vishnu Vardhan Mukkoti, G. Sankaraiah, M. Yohan   +2 more
doaj   +1 more source

The Effect of Technique Change on Knee Loads during Sidestep Cutting [PDF]

, 2007
PURPOSE: To identify the effect of modifying sidestep cutting technique on knee loads and predict what impact such change would have on the risk of noncontact anterior cruciate ligament injury.
Elliott, Bruce C, Dempsey, A.R., Munro, Bridget J., Elliott, B.C., Steele, J.R., Dempsey, Alasdair R, Munro, B.J., Russo, K.A., Elliott, Bruce C., Munro, Bridget J, Steele, Julie R., Lloyd, David G, Russo., Kylie A., Russo, Kylie A, Lloyd, D.G., Lloyd, David G., Steele, Julie R, Dempsey, Alasdair R.   +17 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source