Results 121 to 130 of about 390,130 (351)
INFLUENCE OF PULSED LASER PROCESSING OF CARBIDE CUTTING TOOLS ON METAL CUTTING PERFORMANCE
Advanced Engineering Research, 2010 The results of influence of job stability and cutting instruments hardening on the process efficiency, job primecost and expenses for tools are described.
Igor A. PINAKHIN +2 more
doaj
Experimental study of thin part vibration modes in machining [PDF]
, 2008 The machining of thin walls generally generates milling chatter, that damage surface roughness and manufacturing tools. Stability lobes which include natural frequencies are successful in case of tool chatter.
Arnaud, Lionel +2 more
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Optimization of 5-Axis milling processes based on the process models with application to airfoil machining [PDF]
, 2007 5-axis milling is widely used in machining of complex surfaces such as airfoils. Improper selection of machining parameters may cause low productivity and undesired results during machining.
Budak, Erhan, Tunc, Taner
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Density-operator evolution: Complete positivity and the Keldysh real-time expansion
, 2019 We study the reduced time-evolution of open quantum systems by combining quantum-information and statistical field theory. Inspired by prior work [EPL 102, 60001 (2013) and Phys. Rev. Lett.
Reimer, V., Wegewijs, M. R.
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Вплив попередньої підготовки порошків ВNВ до спікання на основні характеристики процесу обробки сталі ШХ15 в режимі безперервного різання [PDF]
, 2010 Приведені результати досліджень особливостей процесу безперервного точіння загартованої сталі ШХ15 твердістю HRC 62..63 інструментом з композиційного надтвердого матеріалу типу гексаніт-Р, виготовленого по різних технологіях.
Аврамчук, С. К. +4 more
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source