Results 61 to 70 of about 388,520 (305)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

DETAILS’ REPAIR OF CONSTRUCTION AND ROAD MACHINES: FLUCTUATIONS’ MODELLING

Вестник СибАДИ, 2019
Introduction. Hole details are quite widely used in structures of construction and road machines. The specialists apply boring for draft, semi-fair, and in some cases for fair processing of such surfaces.
V. E. Ovsyannikov, V. I. Vasilyev
doaj   +1 more source

Design development of machine shop area for the cover KS6-57.017 manufacture including the study of the cutter micro geometrical deviations in cutting process by finite elements method [PDF]

, 2019
The thesis develops the design of machine shop area for manufacturing the cover and researching the deviations of micro geometrical parameters during the cutting process by finite elements methodCONTENTS INTRODUCTION 1. GENERAL-TECHNICAL CHAPTER 1.
Adusei, Ebenezer, Адусеі, Ебенезер   +1 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

A model of lathe dynamic system when cutting hard-to-work materials

Известия высших учебных заведений. Поволжский регион:Технические науки
Background. Ensuring the surface quality of critical products of aviation equipment, chemical, power engineering, transport systems for various purposes presents certain requirements for the equipment on which surface formation is carried out.
A.A. Ignat'ev, T.G. Nasad, V.A. Dobryakov, V.A. Revyakin   +3 more
doaj   +1 more source

Effect of different modes of high-frequency electric current on structural changes in the optic nerve in rabbits

Journal of Ophthalmology, 2018
An original technique for enucleation of the eyeball with advanced retinoblastoma using high-frequency electric welding of biological tissues (HFEWBT) was developed in SI “Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine” in 2013.
N.F. Bobrova, V.V. Vit, T.A. Sorochinskaya, N.I. Molchanyuk, I.M. Levitsky   +4 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Selection of design and operational parameters in spindle-holder-tool assemblies for maximum chatter stability by using a new analytical model [PDF]

, 2007
In this paper, using the analytical model developed by the authors, the effects of certain system design and operational parameters on the tool point FRF, thus on the chatter stability are studied.
Budak, Erhan, Erturk, Alper, Ertürk, Alper, Ozguven, H. Nevzat, Özgüven, H. Nevzat   +4 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source