Results 41 to 50 of about 59,793 (262)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Research on the roadheader cutting control system based on convolutional neural network and fuzzy PID

Gong-kuang zidonghua
In response to the insufficient adaptability and low system stability of cantilever roadheader when facing changes in coal and rock hardness during tunneling, a roadheader cutting control system based on convolutional neural networks (CNN) and fuzzy PID ...
LI Yingna, CUI Yanping, AN Boshuo, LIU Baijian, JIN Jianwei   +4 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Effect of grain angle on the strain distribution during orthogonal cutting of hinoki (Chamaecyparis obtusa) measured using a digital image correlation method

Journal of Wood Science, 2019
The strain associated with orthogonal cutting with and against the grain of hinoki (Chamaecyparis obtusa) was measured. Digital image correlation method was used to measure strain distributed in the area within 0.5 mm of the cutting edge.
Yosuke Matsuda, Yuko Fujiwara, Yoshihisa Fujii   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Cutting path optimization method for shearer fault crossing based on improved slime mold algorithm and B-spline curve fitting

Gong-kuang zidonghua
Traditional shearer cutting path optimization methods show poor adaptability when dealing with coal seams significantly affected by fault-induced undulations, and it is difficult to ensure the continuity and stability of the cutting path. To address this
HE Zhenliang, LIU Zongjun, LIU Wanli
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Minimizing airtime by optimizing tool path in computer numerical control machine tools with application of A* and genetic algorithms

Advances in Mechanical Engineering, 2017
Research on tool path planning has been limited to minimize airtime by optimizing tool travel path in one machining plane without obstacles. To address this limitation, a method for tool path optimization that exploits A* and genetic algorithms to find ...
Naveen Senniappan Karuppusamy, Bo-Yeong Kang   +1 more
doaj   +1 more source

Optimisation of Planning Parameters for Machining Blade Electrode Micro-Fillet with Scallop Height Modelling

Micromachines, 2021
Aero-engine blades are manufactured by electroforming process with electrodes. The blade electrode is usually machined with five-axis micromilling to get required profile roughness. Tool path planning parameters, such as cutting step and tool tilt angle,
Yue Liu, Zhanqiang Liu, Wentong Cai, Yukui Cai, Bing Wang, Guoying Li   +5 more
doaj   +1 more source