Results 141 to 150 of about 1,085,697 (295)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Research on cutting performance of micro-texturing tools for cutting aluminum alloys

Mechanics & Industry
To address the common issues of high cutting forces, poor surface quality, and chip wrapping in aluminium alloy machining, this study innovatively designed two types of micro-groove textures on the tool surface based on the natural flow direction of ...
Xu Tiantian, Liu Jinpeng, Guan Qingyu, Zhao Wanting, Ma Chunlu   +4 more
doaj   +1 more source

Cutting Performance of Randomly Distributed Active Abrasive Grains in Gear Honing Process. [PDF]

Micromachines (Basel), 2021
Gao Y, Wang F, Liang Y, Han J, Su J, Tong Y, Liu L.   +6 more
europepmc   +1 more source

Towards self-optimizing and self-adaptive milling processes [PDF]

This paper presents a novel control architecture system which is composed of a multi-objective cost function which Pareto optimises the programming of cutting parameters while adapting the milling process to new cutting conditions if new constraints ...
Fletcher, Simon, Longstaff, Andrew P., Myers, Alan, Rubio Rodriguez, Luis   +3 more
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Enhancing cutting performance of cemented carbide rotary burrs through coupled electromagnetic treatments of the burrs

Manufacturing Review
Rotary burrs made of WC-8Co cemented carbide are widely used in automated filing systems, yet rapid cutting-edge wear significantly limits their performance. For this purpose, coupled electromagnetic treatments were applied to the WC-8Co cemented carbide
Zhang Shiyuan, Jiang Ming, Zeng Bo, Chen Wei, Huang Kunlan, Wang Jie   +5 more
doaj   +1 more source

Research on Cutting Performance of Conical Pick Cutting Rock Plate with One Side Constrain and Three Sides Free. [PDF]

Sci Prog, 2022
Lu Z, Wang H, Zeng Q, Wang Z, Wan L, Li C.   +5 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

417 Cutting Performance in Dry Cutting

The Proceedings of Conference of Tokai Branch, 2001
Junichi SHINODA, Eitoku NAKANISHI, Kiyoshi ISOGIMI   +2 more
openaire   +2 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source