Results 121 to 130 of about 1,085,697 (295)

Preparation and cutting performance study of YSZ-toughened PcBN superhard tools. [PDF]

RSC Adv, 2023
Yue Y, Zhu Y, Li Z.
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A Comprehensive Understanding of Knife Cutting: Effects of Hardness, Blade Angle and the Micro-Geometry of Blade Edge on the Cutting Performance. [PDF]

Materials (Basel), 2023
Zhang Q, Liu F, Wu D, Qu S, Liu W, Chen Z.   +5 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Effect of Garnet Characteristics on Abrasive Waterjet Cutting of Hard Granite Rock

Advances in Civil Engineering, 2019
Abrasive waterjet cutting technology has come back into use in the field of rock excavation (such as for tunneling) due to the need for precision construction with low vibration.
Tae-Min Oh, Gun-Wook Joo, Yohan Cha, Gye-Chun Cho   +3 more
doaj   +1 more source

Effect of Coating Thickness on Abrasion and Cutting Performance of NCD-Coated Ball Endmills on Graphite Machining. [PDF]

Micromachines (Basel), 2023
Lee H, Kim J, Lee S, Park J, Park J, Kim J.   +5 more
europepmc   +1 more source

Simulation of broaching operations for tool design optimization [PDF]

, 2010
In this study, an approach for simulation of broaching operations is presented. The proposed approach calculates the cutting forces, power, maximum stress at the tooth root, chip thickness and rake angle distribution on all teeth, and the workpiece ...
Budak, Erhan, Cook, Cristina, El-Wardany, Tahany, Engin, Serafettin, Engin, Şerafettin, Ozlu, Emre, Özlü, Emre   +6 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Analysis and optimization of micro-pit texture parameters on surface of turning tool for GH4169 nickel-based superalloy

Jin'gangshi yu moliao moju gongcheng
ObjectivesGH4169 nickel-based high-temperature alloy is widely used in aerospace and energy equipment fields due to its excellent high-temperature resistance and corrosion resistance, but its difficult-to-machine characteristics lead to high cutting ...
Shankuo YUE, Yan HE, Shuyuan SONG, Lin FAN, Meiling TANG, Jingting SUN   +5 more
doaj   +1 more source