Results 101 to 110 of about 8,927,481 (300)

Cutting performance of diamond-like carbon coated tips in ultrasonic osteotomy

Journal of Dental Sciences, 2014
Background/purpose: Ultrasonic osteotomy has been introduced in oral and maxillofacial surgery in recent years for minimally invasive treatment. The purpose of this study is to evaluate the cutting performance of three different coated tips by the ...
Yunn-Shiuan Liao, Ting-Chang Lin, Cheng-Yu Lai, Yen-Liang Chen, Hao-Hueng Chang, Chun-Pin Lin   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Optimal submerged waterjet for gas recovery based on Arbitrary Lagrange‐Euler

Energy Science & Engineering, 2019
This paper proposes a coupled model of waterjet cutting coal containing gas with the Arbitrary Lagrange‐Euler algorithm assistance. The dynamic evolution of coal damage and the cutting performance under different jet conditions, including jet pattern ...
Long Wang, Zhaofeng Wang, Hai Liu, Jinsheng Chen, Tenglong Yang   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Effect of CO2 laser cutting process parameters on edge quality and operating cost of AISI316L [PDF]

, 2012
Laser cutting is a popular manufacturing process utilized to cut various types of materials economically. The width of laser cut or kerf, quality of the cut edges and the operating cost are affected by laser power, cutting speed, assist gas pressure ...
T. Inoue, Hagino, M., Olabi, Abdul-Ghani, A.G. Olabi, Eltawahni, Hayat, K.Y. Benyounis, H.A. Eltawahni, Benyounis, Khaled, Inoue, T., M. Hagino   +9 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Metal cutting modelling SPH approach [PDF]

, 2011
The purpose of this work is to evaluate the use of the smoothed particle hydrodynamics (SPH) method within the framework of high speed cutting modelling. First, a 2D SPH based model is carried out using the LS-DYNA® software.
J. Limido, Salaün, Michel, J.L. Lacome, R. Chieragatti, Lacome, Jean-Luc, M. Salaun, Chieragatti, Rémy, Mabru, Catherine, C. Espinosa, Espinosa, Christine, Limido, Jérôme, C. Mabru   +11 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Techniques for Enhancing the Cutting Performance of Abrasive Waterjets [PDF]

, 2004
The need to enhance the cutting performance and capability of abrasive waterjet (AWJ) technology has been a focal point in this field of research to increase its application domain.
Wang, Jun
core  

Review on cutting performance and wear mechanism of PCBN tools

Jin'gangshi yu moliao moju gongcheng, 2020
Polycrystalline cubic boron nitride (PCBN) tool is another kind of superhard tool after polycrystalline diamond tool. It is known as the green environmental protection tool in the 21st century for its unique advanced cutting methods such as turning ...
CUI Jinmeng, MENG Dezhong, WU Zhe, YUE Wen, WANG Chengbiao   +4 more
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