Results 101 to 110 of about 1,085,697 (295)

STUDY OF THE CERAMIC CUTTING TOOL PERFORMANCE USING DOUBLE RAKE FACE

open access: yesDiyala Journal of Engineering Sciences, 2008
The objective of this work is to study the effect of the types of ceramic cutting tools on the cutting performance by using double rake tooling. The simulation in this research concerned with the initial cutting process using contact with the workpiece ...
Suha K. Shehab
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Research on Micro⁃Textured CBN Tools for Turning of Copper⁃Nickel Alloy

open access: yesLiaoning Shiyou Huagong Daxue xuebao
Three types of micro⁃textures, including broken line grooves, longitudinal grooves and 45° oblique grooves, were constructed on the tool surface and the influence of the tool surface micro⁃texture on the tool cutting performance during copper⁃nickel ...
Chao ZHANG   +5 more
doaj   +1 more source

Study on the Performances of Cutting Fluids

open access: yesJournal of the Japan Society of Precision Engineering, 1958
In this report, various kinds of cutting fluids on the market have been evaluated from the view points of cost per unit metal removal, surface roughness, power consumption, antirusting ability, etc., when such steels as SK5 and S25C were machined. Thus, cutting fluids suitable for the machining operations in factories were selected.
Kenzi SIRAISI, Koyu KAKAZU
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Incremental evolution strategy for function optimization [PDF]

open access: yes, 2006
This paper presents a novel evolutionary approach for function optimization Incremental Evolution Strategy (IES). Two strategies are proposed. One is to evolve the input variables incrementally.
Guan, SU, Mo, W
core  

Performance Evaluation of Sparse Matrix Multiplication Kernels on Intel Xeon Phi

open access: yes, 2013
Intel Xeon Phi is a recently released high-performance coprocessor which features 61 cores each supporting 4 hardware threads with 512-bit wide SIMD registers achieving a peak theoretical performance of 1Tflop/s in double precision.
E-J Im   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Simulation and Experimental Study on the Effect of Edge Radius on the Cutting Condition of Carbide Inserts

open access: yesMachines
Carbide tools are extensively used in the automotive, aerospace, and marine industries. However, an unsuitable tool-edge treatment can affect the cutting performance of carbide tools.
Shitao Chen   +9 more
doaj   +1 more source

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