Results 91 to 100 of about 157,409 (262)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MetalsThe relationship between the stability of tool materials and their cutting performance is a critical technical challenge for the manufacturing industry, which is essential for selecting appropriate treatment processes to achieve superior treatment tool ...
Fujian Guo +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Design and Test Research on Cutting Blade of Corn Harvester Based on Bionic Principle
Applied Bionics and Biomechanics, 2017 Existing corn harvester cutting blades have problems associated with large cutting resistance, high energy consumption, and poor cut quality. Using bionics principles, a bionic blade was designed by extracting the cutting tooth profile curve of the B ...
Kunpeng Tian +5 more
doaj +1 more source
A Comprehensive Understanding of Knife Cutting: Effects of Hardness, Blade Angle and the Micro-Geometry of Blade Edge on the Cutting Performance. [PDF]
Materials (Basel), 2023 Zhang Q +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Motion Parameters Optimization of Shearer Based on Double-drum Optimization Model
工程科学与技术, 2018 The traditional single-drum optimization model,which only contains the haulage speed and the rotational speed,has been widely used in motion parameter optimization of shearer in academic area.However,the single-drum optimization model cannot totally ...
Yonggang LIU +4 more
doaj
Effect of Coating Thickness on Abrasion and Cutting Performance of NCD-Coated Ball Endmills on Graphite Machining. [PDF]
Micromachines (Basel), 2023 Lee H +5 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Effect of high-speed steel screw drill geometry on cutting performance when machining austenitic stainless steel. [PDF]
Sci Rep, 2023 Sedlak J +4 more
europepmc +1 more source