Results 71 to 80 of about 157,409 (262)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Experimental Research on the Effect of Thermophysical Characteristics of Cutting Fluid on Cutting Performance During Turning Ti-6Al-4V Alloy

Lubricants
Cutting fluid has been widely used to enhance the heat dissipation of cutting systems. However, whether cutting fluid can fully play its role is closely correlated with its thermophysical characteristics, such as viscosity, surface tension, etc.
Xiaorong Zhou, Lin He, Sen Yuan, Jing Deng, Zebin Su, Jingdou Yang, Feilong Du   +6 more
doaj   +1 more source

Cutting Performance and Wear/Damage Characteristics of PCBN Tool in Hard Milling

Applied Sciences, 2019
In the intermittent machining of hardened steel for the die and mold industry, determining how to reduce the wear of PCBN (Polycrystalline Cubic Boron Nitride) tools and improve their machining efficiency and quality is an important subject.
Haining Gao, Xianli Liu, Zhitao Chen
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Effects of TiC Addition on Mechanical Behavior and Cutting Performance of Powder Extrusion Printed Cemented Carbides

Metals
This study addresses the limited research on the mechanical behavior and cutting performance of additive manufactured cemented carbides with high TiC content, which has impeded the rapid development of additive manufacturing in carbide cutting tools ...
Bisheng Zhong, Dezhi He, Xin Deng, Peishen Ni   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

STUDY OF THE CERAMIC CUTTING TOOL PERFORMANCE USING DOUBLE RAKE FACE

Diyala Journal of Engineering Sciences, 2008
The objective of this work is to study the effect of the types of ceramic cutting tools on the cutting performance by using double rake tooling. The simulation in this research concerned with the initial cutting process using contact with the workpiece ...
Suha K. Shehab
doaj   +1 more source

Study on the Performances of Cutting Fluids

Journal of the Japan Society of Precision Engineering, 1958
In this report, various kinds of cutting fluids on the market have been evaluated from the view points of cost per unit metal removal, surface roughness, power consumption, antirusting ability, etc., when such steels as SK5 and S25C were machined. Thus, cutting fluids suitable for the machining operations in factories were selected.
SIRAISI, Kenzi, KAKAZU, Koyu
openaire   +2 more sources