Results 81 to 90 of about 1,085,697 (295)
Design optimization of TBM disc cutters for different geological conditions [PDF]
, 2015 A novel optimization methodology for the disc cutter designs of tunnel boring machines (TBM) was presented. To fully understand the characteristics and performance of TBM cutters, a comprehensive list of performance parameters were investigated ...
Liu, Jingsheng, Xia, Yimin, Zhang, Kui
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Study on the Design and Cutting Performance of a Revolving Cycloid Milling Cutter
Applied Sciences, 2019 Problems such as low machining efficiency, severe tool wear and difficulty in safeguarding surface quality always exist in the machining process of titanium alloy with ball-end milling cutters.
Guangyue Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Optimizing Ranking Measures for Compact Binary Code Learning [PDF]
, 2014 Hashing has proven a valuable tool for large-scale information retrieval. Despite much success, existing hashing methods optimize over simple objectives such as the reconstruction error or graph Laplacian related loss functions, instead of the ...
Lin, Guosheng +2 more
core +2 more sources
Reduce-and-Split Cuts: Improving the Performance of Mixed-Integer Gomory Cuts [PDF]
Management Science, 2005 Mixed-integer Gomory cuts have become an integral part of state-of-the-art software for solving mixed-integer linear programming problems. Therefore, improvements in the performance of these cutting planes can be of great practical value. In this paper, we present a simple and fast heuristic for improving the coefficients on the continuous variables ...
Kent Andersen +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
The Performance of TiAlSiN Coated Cemented Carbide Tools Enhanced by Inserting Ti Interlayers
Metals, 2019 To enhance the cutting performance of TiAlSiN coated cemented carbide tools by inserting Ti interlayers and to explore their mechanism, TiAlSiN/Ti multilayer coatings with different Ti thicknesses, including 0 nm, 25 nm, 50 nm, 100 nm, and 150 nm, were ...
Guodong Li +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source