Results 81 to 90 of about 8,927,481 (300)

Performance Analysis of NbC-based Cutting Materials for dry cylindrical Turning of Carbon Steel

364369Niobium carbide (NbC) is considered an alternative to conventional tungsten carbide (WC) cutting tool materials for steel machining. Due to its high hot hardness and low solubility in metallic matrices at elevated temperatures, NbC is a promising ...
Schneider, Christoph, Günster, Jens, Beer, F., Uhlmann, Eckart   +3 more
core   +1 more source

Computer-aided efficient design and performance optimization of cutting head for roadheader

Scientific Reports, 2022
The cutting head is the core working mechanism of the roadheader for coal-rock materials cutting. The efficient and high performance design of cutting head is the key to improve the road head digging and mining technology. In this paper, based on cutting
Xin Jin, Guochao Zhao, Lijuan Zhao, Guocong Lin   +3 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Analysis and optimization of micro-pit texture parameters on surface of turning tool for GH4169 nickel-based superalloy

Jin'gangshi yu moliao moju gongcheng
ObjectivesGH4169 nickel-based high-temperature alloy is widely used in aerospace and energy equipment fields due to its excellent high-temperature resistance and corrosion resistance, but its difficult-to-machine characteristics lead to high cutting ...
Shankuo YUE, Yan HE, Shuyuan SONG, Lin FAN, Meiling TANG, Jingting SUN   +5 more
doaj   +3 more sources

Study on Cutting Performance of Coated Carbide Tools in Milling of Powder Metallurgy Superalloy

工程科学与技术, 2010
:Based on the analysis of milling characteristic, reasonable geometric parameters of milling cutler and coated carbide grade were selected. Reasonable geometric parameters of insert were also selected through contrast experiment of tool wear resistance ...
Qiao Yang, Ai Xing, Liu Zhanqiang, Zhao Jun   +3 more
doaj  

Research on Micro⁃Textured CBN Tools for Turning of Copper⁃Nickel Alloy

Liaoning Shiyou Huagong Daxue xuebao
Three types of micro⁃textures, including broken line grooves, longitudinal grooves and 45° oblique grooves, were constructed on the tool surface and the influence of the tool surface micro⁃texture on the tool cutting performance during copper⁃nickel ...
Chao ZHANG, Shankuo YUE, Yan HE, Lin FAN, Meiling TANG, Jingting SUN   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Investigating the CO2 laser cutting parameters of MDF wood composite material [PDF]

, 2011
Laser cutting of medium density fibreboard (MDF) is a complicated process and the selection of the process parameters combinations is essential to get the highest quality of the cut section.
Olabi, Abdul-Ghani, A.G. Olabi, Eltawahni, Hayat, K.Y. Benyounis, H.A. Eltawahni, Benyounis, Khaled   +5 more
core   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source