Results 61 to 70 of about 8,927,481 (300)

Study on the Design and Cutting Performance of a Revolving Cycloid Milling Cutter

Applied Sciences, 2019
Problems such as low machining efficiency, severe tool wear and difficulty in safeguarding surface quality always exist in the machining process of titanium alloy with ball-end milling cutters.
Guangyue Wang, Xianli Liu, Weijie Gao, Bingxin Yan, Tao Chen   +4 more
doaj   +1 more source

Cutting performance and tool wear in laser-assisted grinding of SiCf/SiC ceramic matrix composites

Materials Research Express, 2022
Ceramic matrix composites have high hardness, so their machining requires high grinding forces that cause severe wear of the grinding head. To investigate this problem, the present study investigated the cutting performance of conventional grinding (CG ...
Xianjun Kong, Shiwen Liu, Ning Hou, Ming Zhao, Na Liu, Minghai Wang   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Influence of Chip Breaker Geometric Shape on the Cutting Performance of Cermet Tools

Eng
Ti(C,N)-based cermet turning inserts with two distinct chip breaker groove structures were employed to investigate the influence of chip breaker geometry on cutting performance.
Shuwen Yu, Zengmin Shi, Chengui Deng-Li, Junwen Gao, Lei Dai   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The Coupled Influence of Material and Geometric Parameters on Cutting-Edge Micro-Morphology and Wear Property Degradation

Metals
Cutting-edge wear is inevitable in the cutting process of the knife. Studying the relationship between the performance of the knife and the cutting-edge wear is conducive to optimizing the design of the knife and increasing its service life.
Zhimin Peng, Fujian Guo, Wenle Liu, Pan Zhang, Yongjin Mai, Chengjia Shang   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Performance of TiAlSiN Coated Cemented Carbide Tools Enhanced by Inserting Ti Interlayers

Metals, 2019
To enhance the cutting performance of TiAlSiN coated cemented carbide tools by inserting Ti interlayers and to explore their mechanism, TiAlSiN/Ti multilayer coatings with different Ti thicknesses, including 0 nm, 25 nm, 50 nm, 100 nm, and 150 nm, were ...
Guodong Li, Liuhe Li, Mingyue Han, Sida Luo, Jie Jin, Lei Wang, Jiabin Gu, Hu Miao   +7 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Modelling the cutting process and cutting performance in abrasive waterjet machining with controlled nozzle oscillation [PDF]

, 2006
Abrasive waterjet (AWJ) cutting is one of the most recently developed manufacturing technologies. It is superior to many other cutting techniques in processing various materials, particularly in processing difficult-to-cut materials.
Xu, Shunli
core