Results 51 to 60 of about 157,409 (262)

Optimal submerged waterjet for gas recovery based on Arbitrary Lagrange‐Euler

Energy Science & Engineering, 2019
This paper proposes a coupled model of waterjet cutting coal containing gas with the Arbitrary Lagrange‐Euler algorithm assistance. The dynamic evolution of coal damage and the cutting performance under different jet conditions, including jet pattern ...
Long Wang, Zhaofeng Wang, Hai Liu, Jinsheng Chen, Tenglong Yang   +4 more
doaj   +1 more source

Reduce-and-Split Cuts: Improving the Performance of Mixed-Integer Gomory Cuts [PDF]

Management Science, 2005
Mixed-integer Gomory cuts have become an integral part of state-of-the-art software for solving mixed-integer linear programming problems. Therefore, improvements in the performance of these cutting planes can be of great practical value. In this paper, we present a simple and fast heuristic for improving the coefficients on the continuous variables ...
Kent Andersen, Gérard Cornuéjols, Yanjun Li   +2 more
openaire   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Study on the Engineering Technology of the Structural Design of the Index-able Turning Tool

Journal of Harbin University of Science and Technology, 2017
The optimal geometry of the working part of the cutting tool has an important influence on aspects such as high quality parts processing，improvement of production efficiency and the longer tool life in the cutting process.
HE Geng-huang, LI Ling-xiang, ZOU Ling-li, CHENG Cheng, LIU Xian-li   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Application of Cryogenic Minimum Quantity Lubrication Technology in Different Machining Processing for Titanium Alloys: A Review

Lubricants
Titanium alloys face challenges such as high temperatures, high forces, and tool wear during turning, milling, drilling, and grinding operations. Cryogenic minimum quantity lubrication (CMQL) technology, which combines cryogenic cooling with micro ...
Xiangke Tian, Tai Ma, Jie Yang, Qinglong An   +3 more
doaj   +1 more source

Cutting Performance of Microcrystalline, Nanocrystalline and Dual-Layer Composite Diamond Coated Tools in Drilling Carbon Fiber Reinforced Plastics

Applied Sciences, 2018
The drilling of carbon fiber reinforced plastics (CFRP) is a significant topic for the aircraft industry. However, CFRP are materials which are difficult to cut due to their unique properties.
Jianguo Zhang, Yigao Yuan, Jinjiang Zhang   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Influence of Molybdenum Addition on the Structure, Mechanical Properties, and Cutting Performance of AlTiN Coatings

Lubricants
Though AlTiN coating has been intensively studied, there is still a need to develop AlTiN coating to meet the growing demand of industrial machining. One effective way to improve the performance of AlTiN coating is by adding alloying elements.
Tao Yang, Jun Yin, Puyou Ying, Changhong Lin, Ping Zhang, Jianbo Wu, Alexander Kovalev, Min Huang, Tianle Wang, Andrei Y. Grigoriev, Dmitri M. Gutsev, Vladimir Levchenko   +11 more
doaj   +1 more source