Results 111 to 120 of about 1,085,697 (295)

Surrogate modelling for reliability assessment of cutting tools [PDF]

open access: yes, 2013
Currently, cutting tool life for machining operations is correlated to process parameters through the widely applied Taylor functions. The latter are valuable expressions in established practice however their generalised nature does not allow accurate ...
Kolios, Athanasios   +1 more
core  

Combining Text and Formula Queries in Math Information Retrieval: Evaluation of Query Results Merging Strategies

open access: yes, 2015
Specific to Math Information Retrieval is combining text with mathematical formulae both in documents and in queries. Rigorous evaluation of query expansion and merging strategies combining math and standard textual keyword terms in a query are given. It
Aizawa A.   +4 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

An Exploratory Study of Suboxone (Buprenorphine/ Naloxone) Film Splitting: Cutting Methods, Content Uniformity, and Stability [PDF]

open access: yes, 2019
Suboxone films are U.S. Food and Drug Administration approved to treat opioid dependence. While the package insert states that films should not be cut, physicians often prescribe film fractions for treatment and tapering. There is no data to support this
Conn, Kelly   +6 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Enhanced Cutting Performance of 50Cr15MoV Martensitic Stainless Steel Through Controlled Residual Austenite Stability

open access: yesMetals
The relationship between the stability of tool materials and their cutting performance is a critical technical challenge for the manufacturing industry, which is essential for selecting appropriate treatment processes to achieve superior treatment tool ...
Fujian Guo   +6 more
doaj   +1 more source

Design and Test Research on Cutting Blade of Corn Harvester Based on Bionic Principle

open access: yesApplied Bionics and Biomechanics, 2017
Existing corn harvester cutting blades have problems associated with large cutting resistance, high energy consumption, and poor cut quality. Using bionics principles, a bionic blade was designed by extracting the cutting tooth profile curve of the B ...
Kunpeng Tian   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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