Results 121 to 130 of about 408,011 (339)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Semantic Versus Syntactic Cutting Planes

, 2016
In this paper, we compare the strength of the semantic and syntactic version of the cutting planes proof system. First, we show that the lower bound technique of Pudlák applies also to semantic cutting planes: the proof system has feasible interpolation via monotone real circuits, which gives an exponential lower bound on lengths of semantic cutting ...
Filmus, Yuval, Hrubeš, Pavel, LAURIA, MASSIMO   +2 more
openaire   +4 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Justification of Parameters of a Prismatic Device for Fertiliser Distribution Across the Width of the Sub-Blade Area of a Flat-Cutting Working Body

Acta Technologica Agriculturae
Subsurface application of mineral fertilisers is an effective agricultural technique that improves both the quantity and quality of cultivated crops. To ensure uniform distribution of granular mineral fertilisers across the width of a tillage working ...
Kuvaev Anton Nikolaevich, Derepaskin Alexey Ivanovich, Tokarev Ivan Vladimirovich, Polichshuk Yurij Vladimirovich, Binyukov Yurij Viktorovich, Ivanchenko Pavel Grigoryevich, Semibalamut Alexander Viktorovich   +6 more
doaj   +1 more source

Convergence Study of Minimizing the Nonconvex Total Delay Using the Lane-Based Optimization Method for Signal-Controlled Junctions

Discrete Dynamics in Nature and Society, 2012
This paper presents a 2D convergence density criterion for minimizing the total junction delay at isolated junctions in the lane-based optimization framework.
C. K. Wong, Y. Y. Lee
doaj   +1 more source

Optimisasi Keuntungan Penjualan Kopi di Warung Bandar Kopi Deli Serdang dengan Metode Cutting Plane

, 2022
Rina Filia Sari, Rima Aprilia, Hema Pebria Rollingka   +2 more
openalex   +1 more source

Correction to: Designing flexible loop-based material handling AGV paths with cell-adjacency priorities: an efficient cutting-plane algorithm [PDF]

, 2020
Amir Ahmadi‐Javid, Nasrin Ramshe
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

A new cutting plane method for lexicographic multi-objective integer linear programming

, 2023
Marco Cococcioni, Alessandro Cudazzo, Lorenzo Fiaschi, M. Pappalardo, Yaroslav D. Sergeyev   +4 more
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source