Results 131 to 140 of about 2,078,237 (349)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A Finitely Converging Cutting Plane Technique [PDF]
, 1984 We consider a new finitely convergent cutting plane algorithm for mixed integer linear programs in which the optimal objective value is assumed to be integral.
James B. Orlin
core
MathematicsIn this study, we proposed proximal analytic center cutting plane algorithms for solving variational inequalities whose domains are normal regions. Our algorithms stop with a solution of the variational inequality after a finite number of iterations, or ...
Renying Zeng
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Call center staffing with simulation and cutting plane methods [PDF]
, 2002 Call center staffing with simulation and cutting plane ...
Atlason, J. +2 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Research and Realization of Medical Volume Data Interactive Cutting
Journal of Algorithms & Computational Technology, 2010 Medical image visualization is an important field of scientific computing visualization. Three-dimensional segmentation plays a very important role in three-dimensional reconstruction of human tissues and region of interest.
Wu Jian +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
An Efficient Cutting Plane Algorithm for Unconstrained Convex Minimization [PDF]
, 1979 A cutting-plane algorithm is proposed for minimizing a continuously differentiable convex function of n variables. One notable feature of this algorithm is that each cut is actually a supporting hyperplane, which does not require an iterative procedure ...
Solow, Daniel
core
Cutting Plane Algorithms for Semidefinite Relaxations [PDF]
, 1997 We investigate the potential and limits of interior point based cutting plane algorithms for semidefinite relaxations on basis of implementations for max-cut and quadratic 0-1 knapsack problems.
Weismantel, Robert, Helmberg, Christoph
core +2 more sources