Results 71 to 80 of about 408,011 (339)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The Number of Plane Corner Cuts

open access: yesAdvances in Applied Mathematics, 1999
An \(n\)-element subset \(\lambda\) of \(\mathbb{N}^2\) which is cut off a line is called a (plane) corner cut of size \(n\). Let be \({\mathbb{N}^2\choose n}_{ \text{cut}}\) the set of corner cuts of size \(n\). [See \textit{S. Onn} and \textit{B. Sturmfels}, ibid., 29-48 (1999; above).] The authors give a generating for the number \(\#{\mathbb{N}^2 ...
Corteel, Sylvie   +3 more
openaire   +1 more source

Experimental analysis and modeling of orthogonal cutting using material and friction models [PDF]

open access: yes, 2007
In this study, a process model for orthogonal cutting processes is proposed. The model involves the primary and secondary deformation zones. The primary shear zone is modeled by a Johnson-Cook constitutive relationship and a shear plane having constant ...
Budak, Erhan, Ozlu, Emre, Özlü, Emre
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Research into the geometry of the delimbing head of cutting knives

open access: yesResearch in Agricultural Engineering, 2013
Limbing with a wedge tool as a chipless operation is accompanied by a large deformation of wood in the cutting plane, i.e. at the spot of contact with the tool face as well as in the zone adjacent to this plane.
J. Mikleš
doaj   +1 more source

Orbital Conflict: Cutting Planes for Symmetric Integer Programs [PDF]

open access: diamond, 2021
Jeff Linderoth   +4 more
openalex   +1 more source

Cutting Planes for Signomial Programming

open access: yesSIAM Journal on Optimization
Cutting planes are of crucial importance when solving nonconvex nonlinear programs to global optimality, for example using the spatial branch-and-bound algorithms. In this paper, we discuss the generation of cutting planes for signomial programming. Many global optimization algorithms lift signomial programs into an extended formulation such that these
Liding Xu   +3 more
openaire   +3 more sources

Displacements analysis of self-excited vibrations in turning

open access: yes, 2009
The actual research deals with determining by a new protocol the necessary parameters considering a three-dimensional model to simulate in a realistic way the turning process on machine tool.
A Cowley   +26 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Clique problem, cutting plane proofs and communication complexity

open access: yes, 2012
Motivated by its relation to the length of cutting plane proofs for the Maximum Biclique problem, we consider the following communication game on a given graph G, known to both players.
Jukna, S.
core   +1 more source

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