Results 81 to 90 of about 55,445 (267)
A simplified model for determining the cutting plane during thoracoscopic anatomical partial lobectomy of the right lower lobe. [PDF]
Transl Lung Cancer Res, 2021 Liu Y +9 more
europepmc +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
, 2015 The Cutting Plane method is a simple and efficient method for optimizing convex functions in which subgradients are available. This paper proposes several methods for parallelizing it, in particular using a typically evolutionary method, and compares them experimentally in a well-conditioned and ill-conditioned settings.
Decock, Jérémie +2 more
openaire +1 more source
Cutting rectangles in the plane
Discrete Mathematics, 1982 AbstractLet F be a planar family of pairwise disjoint translates of a parallelogram. It is shown that if every four members of F are intersected by some straight line, then there is a straight line which intersects all but at most two members of F. If it is instead assumed that every two members of F are intersected by some line that is parallel to one
Katchalski, Meir, Lewis, Ted
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
MathematicsIn this study, we proposed proximal analytic center cutting plane algorithms for solving variational inequalities whose domains are normal regions. Our algorithms stop with a solution of the variational inequality after a finite number of iterations, or ...
Renying Zeng
doaj +1 more source
Research and Realization of Medical Volume Data Interactive Cutting
Journal of Algorithms & Computational Technology, 2010 Medical image visualization is an important field of scientific computing visualization. Three-dimensional segmentation plays a very important role in three-dimensional reconstruction of human tissues and region of interest.
Wu Jian +4 more
doaj +1 more source