Results 121 to 130 of about 23,957 (296)

Two row mixed integer cuts via lifting [PDF]

Recently, Andersen et al. [1], Borozan and Cornuéjols [6] and Cornuéjols and Margot [9] characterized extreme inequalities of a system of two rows with two free integer variables and nonnegative continuous variables.
WOLSEY, Laurence A., SANTANU, Dey
core  

Unified 2D polygon-based CAM framework integrating tool path generation, machinability evaluation, and cutting-force simulation

Results in Engineering
This study proposes a unified two-dimensional (2D) polygon-based computer-aided manufacturing (CAM) framework that enables tool path generation, machinability evaluation, material removal simulation, and cutting-force prediction within a single ...
Kazuki Kaneko, Hiroto Takayasu, Atsuya Suzuki, Hiroyuki Kodama   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

On Applying Cutting Planes in DLL-Based Algorithms for Pseudo-Boolean Optimization [PDF]

, 2005
Marques-Silva, J. P., Manquinho, V., João Marques-Silva, Vasco Manquinho   +3 more
core   +1 more source

Split rank of triangle and quadrilateral inequalities [PDF]

A simple relaxation of two rows of a simplex tableau is a mixed integer set consisting of two equations with two free integer variables and non-negative continuous variables. Recently Andersen et al.
DEY, Santanu S., LOUVEAUX, Quentin
core  

Evaluation of angulation and distance deviation for robot-guided laser osteotomy – a follow-up study on digital high-tech procedures

Frontiers in Robotics and AI
Background and objectiveConventional osteotomy tools, including drills and saws, have been associated with several limitations, such as restricted cutting geometry and the risk of heat-induced necrosis, which affects bone healing.
Bilal Msallem, Bilal Msallem, Lara Veronesi, Lara Veronesi, Florian Samuel Halbeisen, Michel Beyer, Michel Beyer, Adrian Dragu, Florian Markus Thieringer, Florian Markus Thieringer   +9 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

On the depth of cutting planes

, 2019
We introduce a natural notion of depth that applies to individual cutting planes as well as entire families. This depth has nice properties that make it easy to work with theoretically, and we argue that it is a good proxy for the practical strength of cutting planes.
Poirrier, Laurent, Yu, James
openaire   +2 more sources