Results 121 to 130 of about 2,777,990 (323)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Investigation of Cutting Tools and Working Conditions Effects when Cutting Ti-6al-4V using Vegetable Oil-Based Cutting Fluids [PDF]

, 2015
Power consumed in metal cutting is typically converted into heat near the cutting tool edge. Cutting fluids are then provided to a cutting zone in order to improve the tribological characteristics of machining processes and to dissipate the generated ...
Gariani, Salah, Shyha, Islam, Shyha, I., Gariani, S., Bhatti, M.   +4 more
core   +1 more source

Using of Modified Simplex Imbeddings Method for Solving Special Class of Convex Non-Differentiable Optimization Problems

Известия Иркутского государственного университета: Серия "Математика", 2015
In this paper it is considered the modified simplex imbeddings method, which is related to the class of cutting plane methods. The main feature of this method is the convergence estimation, which depends only on the quantity of simplex vertices, that are
A.V. Kolosnitcyn
doaj  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Unified 2D polygon-based CAM framework integrating tool path generation, machinability evaluation, and cutting-force simulation

Results in Engineering
This study proposes a unified two-dimensional (2D) polygon-based computer-aided manufacturing (CAM) framework that enables tool path generation, machinability evaluation, material removal simulation, and cutting-force prediction within a single ...
Kazuki Kaneko, Hiroto Takayasu, Atsuya Suzuki, Hiroyuki Kodama   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Automatic detection of revealing cutting planes in three-dimensional datasets

, 2006
Cutting planes are useful tools for visualizing the interior of three-dimensional datasets. Placing cutting planes through datasets to produce informative visualizations has traditionally been a manual task.
Carroll, Matthew
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Evaluation of angulation and distance deviation for robot-guided laser osteotomy – a follow-up study on digital high-tech procedures

Frontiers in Robotics and AI
Background and objectiveConventional osteotomy tools, including drills and saws, have been associated with several limitations, such as restricted cutting geometry and the risk of heat-induced necrosis, which affects bone healing.
Bilal Msallem, Bilal Msallem, Lara Veronesi, Lara Veronesi, Florian Samuel Halbeisen, Michel Beyer, Michel Beyer, Adrian Dragu, Florian Markus Thieringer, Florian Markus Thieringer   +9 more
doaj   +1 more source